Posts Tagged ‘EXP’
Calcichew (Calcium Carbonate)
Calcichew 500mg Chewable Tablets
Calcium Carbonate Equivalent to 500mg Calcium
1. WHAT CALCICHEW 500mg ARE AND WHAT THEY ARE USED FOR
Calcichew 500mg are orange flavoured chewable tablets. They contain the active ingredients:
• Calcium (1250mg calcium carbonate: equivalent to 500mg calcium)
Calcium is found in the diet.
Calcichew 500mg may be prescribed by doctors or recommended by pharmacists to treat and prevent calcium deficiency, or when the diet or lifestyle does not provide enough, or when body requirements are increased. This medicine may also be prescribed or recommended for certain bone conditions, for example osteoporosis, or in pregnancy. It may also be given to patients receiving renal dialysis to remove the phosphate from food that cannot be removed by dialysis.
2. BEFORE YOU TAKE CALCICHEW 500mg
Do not take Calcichew 500mg Chewable Tablets if you:
• are allergic (hypersensitive) to any of the ingredients
• have a condition causing high levels of calcium in your blood or urine (hypercalcaemia or hypercalciuria) e.g.
severe kidney failure in people not on dialysis – you should not take this medicine unless advised by your doctor o cancer which has affected your bones
• have kidney stones.
Take special care with Calcichew 500mg:
If any of the following applies to you, please tell your doctor:
• phenylketonuria (a deficiency in the enzyme which breaks down phenylalanine) as these tablets contain aspartame, a source of phenylalanine
• brittle bones (osteoporosis) as a result of being immobile
• taking medicines for your heart, or diuretics
• a high tendency to kidney stone (calculus) formation
• cancer or any other conditions that may have affected your bones.
Your serum calcium or phosphate levels, or urinary calcium excretion must be monitored if you have any of the following conditions.
• kidney problems
• you are on long-term treatment with Calcichew
• you are already taking additional doses of calcium
If you have increased calcium levels in the blood or develop signs of kidney problems, the dose of Calcichew 500mg should be reduced or the treatment discontinued.
Taking other medicines
Please inform your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
In particular, the following medicines may interact with Calcichew 500mg tablets:
• diuretics (water tablets); your serum calcium levels should be monitored regularly.
• heart medicines (cardiac glycosides); you should be monitored by electrocardiogram and your serum calcium levels measured.
• corticosteroids (e.g. prednisolone, dexamethasone); your dose of Calcichew 500mg may need to be increased
• tetracycline antibiotics; these should be taken at least two hours before, or four to six hours afterwards.
• Hormones (levothyroxine); these should be taken at least four hours before, or afterwards.
• Anti-infectives (Quinolones: Ciprofloxacin, lomefloxacin, norfloxacin, sparfloxacin): please speak with your doctor.
• fluoride, or bisphosphonates; Calcichew 500mg should be taken at least three hours afterwards.
Taking Calcichew 500mg with food and drink
Calcichew 500mg should not be taken within 2 hours of eating foods rich in oxalic acid (found in spinach and rhubarb) or phytic acid (found in whole cereals).
Pregnancy and breastfeeding
Ask your doctor or pharmacist for advice if you are pregnant or breast-feeding before taking Calcichew 500mg.
Driving and using machines
Calcichew 500mg has no known effect on your ability to drive or use machines.
Important information about some of the ingredients of Calcichew 500mg
The following are ingredients in this product:
• Sorbitol and isomalt: if you have been told by your doctor that you have an intolerance to some sugars, talk to your doctor before taking this medicine.
• Aspartame contains a source of phenylalanine and may be harmful for people with phenylketonuria (a deficiency in the enzyme which breaks down phenylalanine).
3. HOW TO TAKE CALCICHEW 500MG
Always take Calcichew 500mg exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
For use as additional osteoporosis therapy:
Adults and the elderly: Chew or suck one tablet 2 or 3 times a day.
For calcium deficiency:
Adults, the elderly and children: Chew or suck one tablet 2 or 3 times a day.
For osteomalacia (a softening of the bones):
Adults and the elderly: Chew or suck two to six chewable tablets a day.
As a phosphate binder (for kidney failure patients on dialysis):
When Calcichew 500mg Chewable Tablets are given to patients on kidney dialysis, the dose will be different for each patient. Your doctor will decide how many Calcichew 500mg
Chewable Tablets you need.
The tablets should be taken just before, during or just after each meal to make sure that the calcium binds to the phosphate in the stomach.
If you take more than you should
If you accidentally take more Calcichew 500mg than you should, you may have an increase in your blood calcium levels.
Symptoms of this are: excessive thirst, nausea, vomiting, constipation, abdominal pain, muscle weakness, tiredness, mental disturbances, lack of appetite, bone pain, having to pass more water than usual, kidney problems and, in severe cases, irregular heartbeat.
Very rarely in addition: irritability, continuing headache, lightheadedness, muscle spasms, twitches and tingling sensation.
Do not take any more Calcichew 500mg and contact your doctor or emergency department as soon as possible. Take the packet and any remaining tablets with you.
If you forget to take Calcichew 500mg Chewable Tablets
If you forget to take a dose, leave out that dose completely. Take your next dose when it is due. Do not take a double dose to make up for a forgotten dose.
4. POSSIBLE SIDE-EFFECTS
Like all medicines, Calcichew 500mg can cause side effects, although not everybody gets them.
Side effects with Calcichew 500mg may include:
Uncommon side effects (affecting less than 1 in 100 people):
• too much calcium in your blood (hypercalcaemia) – the symptoms include nausea, vomiting, lack of appetite, constipation, stomach ache, bone pain, extreme thirst, a need to pass more water than usual, muscle weakness, drowsiness and confusion.
• too much calcium in your urine (hypercalciuria)
Rare side effects (affecting less than 1 in 1000 people):
• nausea
• stomach ache
• constipation
• diarrhoea
• wind (flatulence)
• rash
• hives
• itching
Very rare side-effects (affecting less than 1 in 10000 people):
Milk alkali syndrome
If you are taking Calcichew 500mg Chewable Tablets because you are having kidney dialysis, tell your doctor if you notice any white deposits on your skin.
If any of these side-effects become serious, or if you notice any side-effect(s) not listed in this leaflet, please talk to your doctor or pharmacist.
5. HOW TO STORE CALCICHEW 500mg
Keep out of the reach and sight of children.
Store in the original package to protect from moisture. Do not store above 30°C.
Do not use Calcichew 500mg after the expiry date which is stated on the label after EXP. The expiry date refers to the last day of that month. If the tablets have changed shape or colour do not use.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
FURTHER INFORMATION
What Calcichew 500mg Chewable Tablets contain
The active ingredients in each tablet are:
• 1250mg calcium carbonate (equivalent to 500mg calcium)
The other ingredients are: sorbitol (E420), povidone, isomalt (E953), fatty acid mono- and diglycerides, magnesium stearate, orange flavour, and aspartame (E951) .
This product is gluten and lactose free.
Additional Information
Calcichew 500mg contains calcium designed to keep bones healthy. Calcium is an essential component of bones.
Requirements for calcium increase with age and, although many people obtain enough calcium from their diet, some people may require a supplement in order that their body has all the calcium it needs to maintain healthy bones.
People with diets and lifestyles that mean they will obtain less than the recommended intake of calcium are at risk of weakened bones. Prolonged lack of adequate calcium intake can lead to the development of osteoporosis, a condition where bones become weak to a level that minimal trauma (for example, a fall) can result in a fracture, most typically at the hip, spine or wrist.
Calcichew 500mg have been designed to give people, whose intake of calcium is low, a boost to the recommended amounts.
Maintaining healthy bones and helping to avoid osteoporosis is an important issue for many people. There are many ways that people can help themselves: regular exercise, a balanced diet with an adequate intake of calcium and, for some people, advice on how to prevent falls which may lead to fracture.
For patients in the UK, the National Osteoporosis Society (NOS) is a national charity dedicated to improving the diagnosis, prevention and treatment of osteoporosis. The NOS offers support to people with osteoporosis and raises awareness of the importance of healthy bones.
Aromasin (Exemestane)
Aromasin 25 mg Coated tablets
(Exemestane)
1. WHAT AROMASIN IS AND WHAT IT IS USED FOR
Your medicine is called Aromasin. Aromasin belongs to a group of medicines known as aromatase inhibitors. These drugs interfere with a substance called aromatase, which is needed to make the female sex hormones, oestrogens, especially in postmenopausal women. Reduction in oestrogen levels in the body is a way of treating hormone dependent breast cancer.
Aromasin is used to treat hormone dependent early breast cancer in postmenopausal women after they have completed 2-3 years of treatment with the medicine tamoxifen.
Aromasin is also used to treat hormone dependent advanced breast cancer in postmenopausal women when a different hormonal drug treatment has not worked well enough.
2. BEFORE YOU TAKE AROMASIN
Do not take Aromasin
• if you are or have previously been allergic (hypersensitive) to exemestane (the active ingredient in Aromasin) or any of the other ingredients of Aromasin.
• if you have not already been through ‘the menopause’, i.e. you are still having your monthly period.
• if you are pregnant, likely to be pregnant or breastfeeding.
Take special care with Aromasin
• Before treatment with Aromasin, your doctor may want to take blood samples to make sure you have reached the menopause.
• Before taking Aromasin, tell your doctor if you have problems with your liver or kidneys.
• Tell your doctor if you have a history or are suffering from any condition which affects the strength of your bones. Your doctor may want to measure your bone density before and during the treatment of Aromasin. This is because drugs of this class lower the levels of female hormones and this may lead to a loss of the mineral content of bones, which might decrease their strength.
Taking other medicines
Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Aromasin should not be given at the same time as hormone replacement therapy (HRT).
The following medicines should be used cautiously when taking Aromasin. Let your doctor know if you are taking medicines such as:
• rifampicin (an antibiotic).
• carbamazepine or phenytoin (anticonvulsants used to treat epilepsy).
• the herbal remedy St. Johns Wort (Hypericum perforatum), or preparations containing St. Johns Wort.
Pregnancy and breast-feeding
Do not take Aromasin if you are pregnant or breastfeeding.
If you are pregnant or think you might be, tell your doctor.
Discuss contraception with your doctor if there is any possibility that you may become pregnant.
Driving and using machines
If you feel drowsy, dizzy or weak whilst taking Aromasin, you should not attempt to drive or operate machinery.
Important information about some of the ingredients of Aromasin
• If you have previously been told that you have intolerance to some sugars, contact your doctor before taking this medicine. Aromasin tablets contain sucrose (a type of sugar), which may cause a problem in a small number of patients with hereditary intolerance to some sugars (glucose-galactose malabsorption, fructose intolerance or sucrose-isomaltase insufficiency).
• Aromasin contains a small amount of methyl parahydroxybenzoate, which may cause allergic reactions (possibly delayed), if this should happen please contact your doctor.
3. HOW TO TAKE AROMASIN
Adults and the elderly
Aromasin tablets should be taken by mouth after a meal at approximately the same time each day. Your doctor will tell you how to take Aromasin and for how long. The recommended dose is one 25 mg tablet daily. Do not stop taking your tablets even if you are feeling well, unless your doctor tells you.
If you need to go to the hospital whilst taking Aromasin, let the medical staff know what medication you are taking.
Children
Aromasin is not suitable for use in children.
If you take more Aromasin than you should
If too many tablets are taken by accident, contact your doctor at once or go straight to the nearest hospital casualty department. Show them the pack of Aromasin tablets.
If you forget to take Aromasin
Do not take a double dose to make up for a forgotten tablet.
If you forget to take your tablet, take it as soon as you remember. If it is nearly time for the next dose, take it at the usual time.
4. POSSIBLE SIDE EFFECTS
Like all medicines, Aromasin can cause side effects, although not everybody gets them. In general, Aromasin is well tolerated and the following side effects observed in patients treated with Aromasin are mainly mild or moderate in nature. Most of the side effects are associated with a shortage of oestrogen (e.g. hot flushes).
Very common side effects, (affecting more than 1 person in 10):
• Difficulty sleeping
• Headache
• Hot flushes
• Feeling sick
• Increased sweating
• Muscle and joint pain (including osteoarthritis, back pain, arthritis and joint stiffness)
• Tiredness
Common side effects, (affecting between 1 to 10 people in 100):
• Loss of appetite
• Depression
• Dizziness, carpal tunnel syndrome (a combinations of pins and needles, numbness and pain affecting all of the hand except the little finger)
• Stomach ache, vomiting (being sick), constipation, indigestion, diarrhoea
• Skin rash, hair loss
• Thinning of bones which might decrease their strength (osteoporosis), leading to bone fractures (breaks or cracks) in some cases
• Pain, swollen hands and feet
Uncommon side effects, (affecting between 1 to 10 people in 1000):
• Drowsiness
• Muscle weakness
Inflammation of the liver (hepatitis) may occur. Symptoms include feeling generally unwell, nausea, jaundice (yellowing of the skin and eyes), itching, right sided abdominal pain and loss of appetite. Contact your doctor promptly if you think you have any of these symptoms.
If you have any blood tests done, it may be noticed that there are changes in your liver function. Changes in the amount of certain blood cells (lymphocytes) and platelets circulating in your blood-may occur, especially in patients with a pre-existing lymphopenia (reduced lymphocytes in the blood).
If any side effects gets serious or if you notice any side effect not listed on this leaflet, please tell your doctor or your pharmacist as soon as possible.
5. HOW TO STORE AROMASIN
• This medicine does not require any special storage conditions.
• Keep your tablets in the original pack.
• As with all medicines, keep them in safe place out of the reach and sight of children.
• Do not use Aromasin after expiry date which is stated on the outer carton and the blister after EXP. The expiry date refers to the last day of the month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
6. FURTHER INFORMATION
What Aromasin contains
• The active substance is exemestane. Each coated tablet contains 25 mg exemestane.
• The other ingredients are silica colloidal hydrated, crospovidone, hypromellose, magnesium stearate, mannitol, microcrystalline cellulose, sodium starch glycollate (type A), polysorbate, polyvinyl alcohol, simeticone, macrogol, sucrose, magnesium carbonate light, methyl parahydroxybenzoate (E218), cetyl esters wax, talc, carnauba wax, ethyl alcohol, shellac, titanium oxide (E171) and iron oxides (E172).
What Aromasin looks like and contents of the pack
Aromasin is a round, biconvex, off-white, coated tablet marked 7663 on one side. Aromasin is available in blister packs of 15, 20, 30, 90, 100 and 120 tablets. Not all pack sizes will be marketed.
Abraxane (Paclitaxel)
Abraxane 5 mg/ml powder for suspension for infusion
Paclitaxel
1. WHAT ABRAXANE IS AND WHAT IT IS USED FOR
Abraxane is a medicine containing paclitaxel albumin. Albumin is a part of human blood. Paclitaxel belongs to a group of medicines called taxanes used to treat cancers.
Abraxane is used for the treatment of breast cancer when other therapies have been tried but have not worked and if you are unsuitable for anthracycline containing treatments.
2. BEFORE YOU USE ABRAXANE
Do not use Abraxane
• if you are allergic (hypersensitive) to paclitaxel or any of the other ingredients of Abraxane;
• if you are breastfeeding;
• if you have a low white blood cell count (baseline neutrophil counts <1.5 x 109/1 – your doctor will advise you on this).
Take special care with Abraxane
• if you have poor kidney function;
• if you experience numbness, tingling, pricking sensations, sensitivity to touch, or muscle weakness;
• if you have severe liver problems;
• if you have heart problems.
If you experience any of these conditions your doctor may wish to stop treatment or reduce the dose.
Taking other medicines
Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription, because they could interact with Abraxane.
Using Abraxane with food and drink
Abraxane is unaffected by food and drink.
Pregnancy and breast-feeding
Paclitaxel may cause serious birth defects and should therefore not be used if you are pregnant.
Women of childbearing age should use effective contraception during and up to 1 month after receiving treatment with Abraxane. Male patients are advised to not father a child during and up to six months after treatment and should seek advice on conservation of sperm prior to treatment because of the possibility of irreversible infertility due to therapy with Abraxane.
It is not known if paclitaxel passes into breast milk. Because of the possibility of harm to the infant, breast-feeding must be discontinued for the duration of treatment.
Ask your doctor for advice before taking this medicine.
Driving and using machines
Abraxane may cause side effects such as tiredness (very common) and dizziness (common) that may affect your ability to drive and use machinery. If you experience these symptoms, do not drive or operate machinery until they have fully resolved.
If you are given other medicines as part of your treatment, you should ask your doctor for advice on driving and using machines.
Important information about some of the ingredients of Abraxane
This medicine contains approximately 425 mg sodium per dose. This should be taken into consideration by patients on a controlled sodium diet.
3. HOW TO USE ABRAXANE
Abraxane will be given to you by a doctor or nurse into a vein from an intravenous drip. The dose you receive is based on your body surface area and blood test results. The usual dose is 260 mg/m2 of body surface area.
How often will you receive Abraxane?
Abraxane is usually given every three weeks.
How long will it take to give you your intravenous drip?
Abraxane is given over a 30 minute period.
If you have any further questions on the use of this medicine, ask your doctor.
4. POSSIBLE SIDE EFFECTS
Like all medicines, Abraxane can cause side effects, although not everyone gets them.
The frequency of possible side effects listed below is defined using the following convention: very common (affects more than 1 user in 10) common (affects 1 to 10 users in 100)
uncommon (affects 1 to 10 users in 1,000)
rare (affects 1 to 10 users in 10,000)
very rare (affects less than 1 user in 10,000)
not known (frequency cannot be estimated from the available data).
The very common side effects are: Loss of hair, rash
Abnormal decrease in the number of neutrophils in the blood Decrease in the number of white blood cells in the blood Deficiency of red blood cells
Reduction in the number of lymphocytes in the blood Reduction in the number of platelets in the blood Effect of peripheral nerves (pain, and numbness) Pain in a joint or joints Pain in the muscles
Nausea, diarrhoea, constipation, sore mouth, loss of appetite Vomiting Weakness and tiredness, fever
The common side effects are:
- Itching, dry skin, nail disorder
- Infection, fever with decrease in the number of neutrophils in the blood, flushing
- Chest, throat or abdominal pain, headache
- Indigestion, abdominal discomfort
- Difficulty in breathing
- Dehydration, taste disturbance, weight loss, hypokalaemia
- Pain in extremities, back or limbs, bone pain, muscle cramps
- Dizziness, diminished muscular coordination or difficulty in reading, increased or decreased
- tears, loss of eyelashes
- Changes in heart rate or rhythm
- Swelling of mucosal and soft tissues
- Sleep problems, depression, anxiety
- Increased liver function tests
The uncommon side effects are:
• Increased blood pressure, increased weight, increased lactate dehydrogenase in the blood, decreased kidney function, increased blood sugar, increased phosphorus in the blood, decreased potassium in the blood
• Nerve disorder, decreased or lack of reflexes, involuntary movements, pain along a nerve, loss of feeling, fainting, dizziness when standing up, painful numbness or tingling, shaking
• Irritated eyes, painful eyes, red eyes, itchy eyes, blurred or double vision, reduced vision, or seeing flashing lights
• Ear pain, ringing in your ears
• Coughing with phlegm, shortness of breath when walking or climbing stairs, stuffy nose, runny nose, or dry nose, decreased breath sounds, water on the lung, loss of voice, difficulty breathing, blood clot in the lung
• Difficulty swallowing, gas, dry mouth, loose stools, heartburn, stomach cramps, painful or sore mouth and gums, rectal bleeding
• Painful urination, frequent urination, blood in the urine, inability to hold your urine
• Fingernail pain, fingernail discomfort, loss of fingernails, hives, skin pain, red skin from sunlight, skin discolouration, red rash, itchy rash, increased sweating, night sweats, white areas on the skin, less hair, overall itching, sores, swollen face
• Decreased phosphorus in the blood, fluid retention, low albumin in the blood, increased thirst, decreased calcium in the blood, decreased sugar in the blood, decreased sodium in the blood
• Thrush, pain and swelling in the nose and throat, skin infections, infection in the lungs, infection due to catheter line, infection, redness or swelling at the site where the needle entered the body
• Bruising
• Pain at site of tumour, death of the tumour
• Decreased blood pressure, decreased blood pressure when standing up, coldness in your hands and feet
• Chest pain or heaviness, difficulty walking, swelling
• Allergic reaction
• Decreased liver function, increased size of liver
• Pain in the breast
• Restlessness
The rare side effects are:
• Reduced blood cells
• Lung infection
• Skin reaction to another agent or lung inflammation following radiation
• Blood clot
• Very slow pulse, heart attack, heart failure.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor.
5. HOW TO STORE ABRAXANE
Keep out of the reach and sight of children.
Do not use Abraxane after the expiry date which is stated on the carton and the vial after EXP. The expiry date refers to the last day of that month.
Unopened vials: This medicine does not require any special temperature storage conditions. Keep the vial in the outer carton in order to protect from light.
After first reconstitution the suspension should be used immediately. If not used immediately, the suspension may be stored in a refrigerator (2°C-8°C) for up to 8 hours in the vial when kept in the outer carton in order to protect it from light.
The reconstituted suspension in the intravenous drip may be stored for up to 8 hours at a temperature not above 25°C.
6. FURTHER INFORMATION
What Abraxane contains
• The active substance is paclitaxel. Each vial contains 100 mg of paclitaxel (as paclitaxel albumin).
• After reconstitution, each ml of suspension contains 5 mg of paclitaxel.
• The other ingredient is human albumin (containing sodium, sodium caprylate and N-acetyl DL tryptophanate).
What Abraxane looks like and contents of the pack
Abraxane is a white to yellow powder for suspension for infusion available in glass vials containing 100 mg paclitaxel. Each pack contains 1 vial.
Instructions for use, handling and disposal
- Preparation and administration precautions
Paclitaxel is a cytotoxic anticancer medicinal product and, as with other potentially toxic compounds, caution should be exercised in handling Abraxane. Gloves, goggles and protective clothing should be used. If Abraxane suspension contacts the skin, the skin should be washed immediately and thoroughly with soap and water. If Abraxane contacts mucous membranes, the membranes should be flushed thoroughly with water. Abraxane should only be prepared and administered by personnel appropriately trained in the handling of cytotoxic agents. Pregnant staff should not handle Abraxane.
- Reconstitution of the product and administration
Abraxane should be administered under the supervision of a qualified oncologist in units specialised in the administration of cytotoxic agents.
Abraxane is supplied as a sterile lyophilised powder for reconstitution before use. After reconstitution, each ml of suspension contains 5 mg of paclitaxel.
Using a sterile syringe, 20 ml of sodium chloride 9 mg/ml (0.9%) solution for infusion should be injected into a vial of Abraxane over a minimum of 1 minute. The solution should be directed onto the inside wall of the vial. The solution should not be injected directly onto the powder as this will result in foaming.
Once the addition is complete, the vial should be allowed to stand for a minimum of 5 minutes to ensure proper wetting of the solid. Then, the vial should gently and slowly be swirled and/or inverted for at least 2 minutes until complete resuspension of any powder occurs. The generation of foam should be avoided. If foaming or clumping occurs, the suspension should stand for at least 15 minutes until foam subsides.
The reconstituted suspension should be milky and homogenous without visible precipitates. If precipitates or settling are visible, the vial should be gently inverted again to ensure complete resuspension prior to use. Some settling of the reconstituted suspension may occur. Complete resuspension should be ensured by mild agitation of the vial before use.
If precipitates are observed, the reconstituted suspension should be discarded.
The exact total dosing volume of 5 mg/ml suspension required for the patient should be calculated and the appropriate amount of reconstituted Abraxane should be injected into an empty, sterile, polyvinyl chloride (PVC) type IV bag. The use of specialized DEHP-free solution containers or administration sets is not necessary to prepare or administer Abraxane infusions. In-line filters should not be used.
Parenteral medicinal products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
Any unused product or waste material should be disposed of in accordance with local requirements.
- Stability
Unopened vials of Abraxane are stable until the date indicated on the package when the vial is kept in the outer carton in order to protect from light. Neither freezing nor refrigeration adversely affects the stability of the product. This medicinal product does not require any special temperature storage conditions.
- Stability of the reconstituted suspension in the vial
After first reconstitution, the suspension should be filled into an infusion bag immediately. However, chemical and physical in use stability has been demonstrated for 8 hours at 2°C-8°C in the original carton, and protected from bright light.
- Stability of the reconstituted suspension in the infusion bag
After reconstitution, the reconstituted suspension in the infusion bag should be used immediately. However chemical and physical in use stability has been demonstrated for 8 hours not above 25°C.