Last updated on May 12, 2023
Duloxetine reduces symptoms of depression.
Duloxetine, an investi-gational antidepressant agent, called a dual reuptake inhibitor, was shown to be superior to placebo in reducing the severity of depressive symptoms. The Phase II data came from a multisite trial of 173 patients with major depression who randomly received either duloxetine, fluoxetine or placebo for eight weeks. The drug was well-tolerated.