Antigout preparations

Rasburicase is a recombinant form of the enzyme urate oxidase. The most serious adverse effects of rasburicase involve hypersensitivity reactions, including anaphylaxis, rashes, bronchospasm, rhinitis, urticaria, hypotension, dyspnoea, and chest pain and tightness. Haemolysis and methaemoglobinaemia have also been reported.

Practically insoluble in water; sparingly soluble in alcohol; freely soluble in acetone and in dichloromethane. Benzbromarone may cause gastrointestinal adverse effects, especially diarrhoea. It may precipitate an acute attack of gout and cause uric acid renal calculi and renal colic.

Allopurinol belongs to a group of medicines called enzyme inhibitors which is used for the long term prevention of gout, the prevention of kidney stones and the treatment of high levels of uric acid associated with tumours and their treatment, certain enzyme disorder in particular Lesch Nyhan syndrome.

Very slightly soluble in water; sparingly soluble in alcohol; dissolves in dilute solutions of alkali hydroxides. Practically insoluble in water and in petroleum spirit; soluble in alcohol and in acetone; sparingly soluble in dilute alkali.

Practically insoluble in water; sparingly soluble in dehydrated alcohol; soluble in acetone. A white or practically white, fine, practically odourless, crystalline powder. Practically insoluble in water and in dilute acids; soluble in alcohol, in acetone, in chloroform, and in dilute alkali.