Antigout preparations

Urate Oxidase

Rasburicase is a recombinant form of the enzyme urate oxidase. The most serious adverse effects of rasburicase involve hypersensitivity reactions, including anaphylaxis, rashes, bronchospasm, rhinitis, urticaria, hypotension, dyspnoea, and chest pain and tightness. Haemolysis and methaemoglobinaemia have also been reported.

Benzbromarone

Practically insoluble in water; sparingly soluble in alcohol; freely soluble in acetone and in dichloromethane. Benzbromarone may cause gastrointestinal adverse effects, especially diarrhoea. It may precipitate an acute attack of gout and cause uric acid renal calculi and renal colic.

ALLOPURINOL

Cancer chemotherapy drugs or radiation therapy are given to kill cancer cells in the body. One of the waste products of the dead cancer cells is uric acid. If uric acid builds up in the body, it can cause kidney damage or joint pain (called gout).

Allopurinol

Allopurinol is a tautomeric mixture of 1H-pyrazolo[3,4-d]pyrimidm-4-ol and l,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one. Very slightly soluble in water and in alcohol; dissolves in dilute solutions of alkali hydroxides.

Sulfinpyrazone

Very slightly soluble in water; sparingly soluble in alcohol; dissolves in dilute solutions of alkali hydroxides. Practically insoluble in water and in petroleum spirit; soluble in alcohol and in acetone; sparingly soluble in dilute alkali.

Probenecid

Practically insoluble in water; sparingly soluble in dehydrated alcohol; soluble in acetone. A white or practically white, fine, practically odourless, crystalline powder. Practically insoluble in water and in dilute acids; soluble in alcohol, in acetone, in chloroform, and in dilute alkali.

Colchicine

Colchicine is an alkaloid obtained from various Colchicum spp. A yellowish-white amorphous or crystalline powder.