Drug Nomenclature
INN: Alizapride Hydrochloride [rINNM (en)]Adverse Effects and Precautions
As for Metoclopramide.
Pharmacokinetics
Alizapride is well absorbed from the gastrointestinal tract. It is mainly excreted unchanged in the urine and has an elimination half-life of about 3 hours.
Uses and Administration
Alizapride is a substituted benzamide similar to metoclopramide, which is used to control nausea and vomiting associated with a variety of disorders. It is given as the hydrochloride but doses are expressed in terms of the base. Alizapride 50 mg is equivalent to about 55.8 mg of alizapride hydrochloride.
Alizapride hydrochloride is given in usual oral doses equivalent to 75 to 300 mg of alizapride daily in divided doses. For children’s doses, see below. It is also given by intravenous or intramuscular injection in doses equivalent to 50 to 200 mg of alizapride daily.
For patients receiving cancer chemotherapy usual daily doses equivalent to alizapride 2 to 5 mg/kg have been given intravenously or intramuscularly in 2 divided doses, one 30 minutes before and one 4 to 8 hours after the cytotoxic regimen. For highly emetic regimens requiring doses above 5 mg/kg it may be given by intravenous infusion over 15 minutes every 2 hours for 5 doses, starting 30 minutes before the cytotoxic. It has been recommended that the total dose given with a course of chemotherapy does not exceed 4.5 g.
Administration in children
Alizapride hydrochloride has been given to children for the symptomatic treatment of nausea and vomiting in oral doses equivalent to 5 mg/kg of alizapride daily.
Proprietary Preparations
Argentina: Gastrivenan
Belgium: Litican
Brazil: Superan
France: Plitican
Germany: Vergentan
Italy: Limican
Portugal: Plitican
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