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Antacids: Aluminium

Aceglutamide Aluminium

Antacids: AluminiumDrug Nomenclature

Synonyms: Aceglutamida de aluminio; Aceglutamide Aluminium; KW-110
USAN: Aceglutamide Aluminium
INN: Aceglutamide Aluminium [rINNM (en)]
INN: Aceglutamida de aluminio [rINNM (es)]
INN: Acéglutamide d’Aluminium [rINNM (fr)]
INN: Aluminii Aceglutamidum [rINNM (la)]
INN: Алюминий Ацеглутамид [rINNM (ru)]
Chemical name: Pentakis (N2-acetyl-l-glutaminato)tetrahydroxytrialuminium
Molecular formula: C35H59Al3N10O24 =1084.8
CAS: 12607-92-0

Pharmacopoeias. In Japan.

Profile

Aceglutamide aluminium, a complex of aceglutamide with aluminium hydroxide, is an antacid with general properties similar to those of aluminium hydroxide. It is given orally in a usual dose of 700 mg three times daily.

Proprietary Preparations

Japan: Glumal.

Aluminium Formate

Drug Nomenclature

Aluminium Triformate.
Муравьинокислый Алюминий; Формиат Алюминия
Al(CHO2)3,3H2O = 216.1.
CAS — 7360-53-4 (anhydrous aluminium formate).

Profile

Aluminium formate has astringent properties and has been used in topical preparations for mouth disorders.

Preparations

Proprietary Preparations

Germany: Dynexan Zahnfleischtropfen.

Multi-ingredient

Austria: Cional Dynexan Methyment

South Africa: Dynexan.

Aluminium Glycinate

Drug Nomenclature

Date of monograph revision: 11-Sep-1996; 02-Mar-1998; 09-Aug-2000; 16-Oct-2001; 10-May-2004; 08-Mar-2006; 20-Jul-2006
Synonyms: Aluminio, glicinato de; Basic Aluminium Aminoacetate; Dihydroxyaluminum Aminoacetate
Chemical name: (Glycinato-N,O)dihydroxyaluminium hydrate
Molecular formula: C2H6AlNO4(+xH2O) =135.1 (anhydrous)
CAS: 13682-92-3 (anhydrous aluminium glycinate); 41354-48-7 (aluminium glycinate hydrate)
ATC code: A02AB07

Pharmacopoeias. In British and US.

BP 2008 (Aluminium Glycinate). A white or almost white, odourless or almost odourless, powder. It contains 34.5 to 38.5% of Al203 calculated on the dried substance, and not more than 12% loss of weight on drying. Practically insoluble in water and in organic solvents it dissolves in dilute mineral acids and in aqueous solutions of alkali hydroxides. A 4% suspension in water has a pH of 6.5 to 7.5.

The United States Pharmacopeia 31, 2008 (Dihydroxyaluminum Aminoacetate). A white, odourless, powder. It may contain small amounts of aluminium oxide and aminoacetic acid. It loses not more than 14.5% of its weight on drying. Insoluble in water and in organic solvents soluble in dilute mineral acids and in solutions of fixed alkalis. A 4% suspension in water has apH of 6.5 to 7.5.

Profile

Aluminium glycinate is an antacid with general properties similar to those of aluminium hydroxide (below). It has been given in doses of up to 1 g by mouth.

Preparations

The United States Pharmacopeia 31, 2008: Dihydroxyaluminum Aminoacetate Magma.

Proprietary Preparations

Denmark: Almin.

Multi-ingredient

Argentina: Dafne

Austria: Gastripan

Belgium: Alucid

Chile: Sinacid

Denmark: Alminox

France: Acidrine

Germany: Acidrine

Greece: Novalox

Italy: Acidrine

Poland: Proacid

Spain: Gastroglutal Meteo-ril Natrocitral Secrepat.

Used as an adjunct in

Austria: Ambene N Indobene

Brazil: Reumix Somalgin

Chile: Butartrol Flexono

Germany: Indomet-ratiopharm m

Italy: Aspirina 03

Switzerland: Bonidon

USA: Buffex.

Aluminium Hydroxide-Magnesium Carbonate Co-dried Gel

Drug Nomenclature

Synonyms: F-MA 11; Hidróxido de aluminio y carbonato de magnesio desecado, gel de

Profile

Aluminium hydroxide-magnesium carbonate co-dried gel is a co-precipitate of aluminium hydroxide and magnesium carbonate dried to contain a proportion of water for antacid activity. It is an antacid with general properties similar to those of aluminium hydroxide (above) and magnesium carbonate. It has been given in oral doses of about 450 to 900 mg, usually 3 times daily after meals and before bedtime.

Preparations

Proprietary Preparations

Denmark: Link

Finland: Link PeeHoo

Greece: Regla pH

Indonesia: Stomacain Veragel

Mexico: Gelasim

The Netherlands: Regla pH Remegel

Norway: Link

Sweden: Link

UK: Dijex.

 

Multi-ingredient

 

Belgium: Barexal Nozid Regla pH Forte Syngel

Brazil: Andursil

Canada: Diovol Diovol Plus Gastrocalm Thunas Hyperacidity Tablets

Chile: Algicote Disfrutab Ditopax

France: Gastropulgite

Germany: Colina Spezial Duoventrinetten N

Hong Kong: Diovol Plus Simeco Veragel

Indonesia: Aludonna Di-Gel Farmacrol Gastran Oskamag Polycrol Simeco

Ireland: Algicon

Israel: Silain

Mexico: Algicon Ditopax Ditopax

The Netherlands: Algicon Muthesa N Rigoletten

Portugal: Di-Gel Di-Gel Forte

Russia: Gastal

Singapore: Meclosil Veragel DMS

Spain: Acilene Acylene

Switzerland: Anacidol Andursil Gastropulgitef Refluxine

Thailand: Defomil Diovol Kremil Kremil-S Machto Simeco Veragel

UK: Algicon Simeco

Venezuela: Ditosil.

Used as an adjunct in

Indonesia: Rheumapill.

Aluminium Phosphate

Aluminium PhosphateDrug Nomenclature

Synonyms: Aliuminio fosfatas; Alumínium-foszfát; Alumiinifosfaatti; Aluminii Phosphas; Aluminio, fosfato de; Aluminiumfosfat; Aluminum Phosphate; Fosforečnan hlinitý
CAS: 7784-30-7 (AlPO4)
ATC code: A02AB03

Pharmacopoeias. In Vietnam. Europe includes hydrated aluminium phosphate and also a gel. US includes as a gel.

European Pharmacopoeia, 6th ed. (Aluminium Phosphate, Hydrated Aluminii Phosphas Hydricus Dried Aluminium Phosphate BP 2008). A white or almost white powder. Very slightly soluble in water practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides and mineral acids. A 4% suspension in water has a pH of 5.5 to 7.2. Store in airtight containers.

European Pharmacopoeia, 6th ed. (Aluminium Phosphate Gel Aluminii Phosphatis Li-quamen). It is aluminium phosphate in gel form containing 19 to 21% of A1P04. Practically insoluble in water, in alcohol, and in dichloromethane. It dissolves in dilute solutions of mineral acids. pH 6.0 to 8.0. Store in airtight containers.

The United States Pharmacopeia 31, 2008 (Aluminum Phosphate Gel). A 4 to 5% suspension of aluminium phosphate (AlPO4) in water and has a pH of 6.0 to 7.2. It is a white viscous suspension from which small amounts of water separate on standing. Store in airtight containers.

Profile

Aluminium phosphate is an antacid with general properties similar to those of aluminium hydroxide, but it does not produce phosphate depletion.

Aluminium phosphate is also used as an adjuvant in adsorbed vaccines.

Preparations

The United States Pharmacopeia 31, 2008: Aluminum Phosphate Gel.

Proprietary Preparations

 

Austria: Phosphalugel

Belgium: Phosphalugel

Czech Republic: Gasterin

France: Phosphalugel

Germany: Phosphalugel

Italy: Fosfalugel

Portugal: Phosphalugel

Russia: Phosphalugel

Switzerland: Phosphalugel

 

Multi-ingredient

Austria: Phoscortil

France: Moxydar Seroxydar

Aluminium Sodium Silicate

Drug Nomenclature

Synonyms: E554; Silicato de sodio y de aluminio; Sodium Aluminium Silicate; Sodium Aluminosilicate; Sodium Silicoaluminate
CAS: 1344-00-9

Profile

Aluminium sodium silicate is an antacid with general properties similar to those of aluminium hydroxide. Aluminium silicate has been used similarly. They are also used as food additives.

Preparations

Proprietary Preparations

France: Sulfuryl

Portugal: Acnoil Free.

 

Multi-ingredient

Austria: Diphlogen

France: Anti-H Cerat Inalterable Sulfuryl

Germany: Enelbin-Paste N Sulfredox

Hong Kong: Epilon

Portugal: Mucal

Thailand: Ulgastrin.

Basic Aluminium Carbonate

Drug Nomenclature

Synonyms: Aluminium Hydroxycarbonate; Basic Aluminium Carbonate; Carbonato básico de aluminio
USAN: Aluminum Carbonate, Basic

Profile

Basic aluminium carbonate is a combination of aluminium hydroxide and aluminium carbonate. It is an antacid with general properties similar to those of aluminium hydroxide (below). Basic aluminium carbonate has also been given orally as a phosphate binder in the treatment of hyperphosphataemia. For a discussion of the choice of phosphate binders, see Renal Osteodystrophy.

Multi-ingredient

Portugal: Gastropensan

Dihydroxyaluminum Sodium Carbonate

Drug Nomenclature

Synonyms: Aluminium Sodium Carbonate Hydroxide; Carbonato sódico de dihidroxialuminio; Dihydroksialuminiumnatriumkarbonaatti; Dihydroxialuminiinatrii Carbonas; Dihydroxialuminiumnatriumkarbonat; Dihydroxyaluminium Sodium Carbonate
Chemical name: Sodium (carbonato)dihydroxyaluminate(1-)
Molecular formula: CH2AlNaO5 =144.0
CAS: 41342-54-5 (carbaldrate); 12011-77-7 (dihydroxyaluminium sodium carbonate); 16482-55-6 (dihydroxyaluminium sodium carbonate)

Note. The name Carbaldrate (rINN) has been applied to (CH2AlNaO5,nH2O), a form of sodium (carbonato)dihydroxyaluminate(1-) hydrate.

Pharmacopoeias. In US.

The United States Pharmacopeia 31, 2008 (Dihydroxyaluminum Sodium Carbonate). A fine white odourless powder. It loses not more than 14.5% of its weight on drying. Practically insoluble in water and in organic solvents; soluble in dilute mineral acids with the evolution of carbon dioxide. A 4% suspension in water has a pH of 9.9 to 10.2. Store in airtight containers.

Profile

Dihydroxyaluminum sodium carbonate is an antacid with general properties similar to aluminium hydroxide that is given in doses of about 300 to 600 mg by mouth.

Preparations

The United States Pharmacopeia 31, 2008: Dihydroxyaluminum Sodium Carbonate Tablets.

Proprietary Preparations

Austria: Antacidum

Denmark: Noacid

Germany: Kompensan

Poland: Alugastrin Gastrinal

Portugal: Kompensan

Switzerland: Kompensan

Turkey: Dank Kompensan.

 

Multi-ingredient

 

Germany: Kompensan-S

Portugal: Kompensan-S

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