Described in this site are:
- Alizapride
- Aprepitant
- Azasetron
- Bromopride
- Cerium Oxalate
- Clebopride
- Difenidol
- Dolasetron
- Domperidone
- Dronabinol
- Fosaprepitant
- Ginger
- Granisetron
- Indisetron
- Itopride
- Mecloxamine Citrate
- Metoclopramide
- Metopimazine
- Nabilone
- Ondansetron
- Palonosetron
- Ramosetron
- Tropisetron
Fosaprepitant
Drug Nomenclature
Fosaprépitant; Fosaprepitantum.
{3-[((2R,3S)-2-{(1R)-1-[3,5-bis(Trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl)methyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}phosphonic acid.
Фозапрепитант
C23H22F7N4O6P = 614.4.
CAS — 172673-20-0.
Fosaprepitant Meglumine
Drug Nomenclature
Fosaprepitant Dimeglumine; Fosaprepitant meglumina; Fosaprépitant
Méglumine; Meglumini Fosaprepitantum; MK-0517.
1-Deoxy-1-(methylamino)-D-glucitol {3-[((2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)-4-morpholinyl)methyl]- 2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl}phosphonate.
Меглумина Фозапрепитант
C23H22F7N4O6P, 2C7H17NO5 = 1004.8.
CAS — 265121-04-8.
Stability. US licensed product information states that, once reconstituted and diluted as directed in sodium chloride 0.9%, a solution of fosaprepitant meglumine is stable for 24 hours at room temperature (at or below 25°).
Adverse Effects and Precautions
As for Aprepitant.
Interactions
As for Aprepitant.
Pharmacokinetics
Fosaprepitant is rapidly converted to aprepitant for the pharmacokinetics of aprepitant.
Uses and Administration
Fosaprepitant is aprodrug of the antiemetic aprepitant, which is a neurokinin-1 receptor antagonist. Fosaprepitant meglumine is used for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic or moderately emetogenic cancer chemotherapy. Doses are expressed in terms of the base 188 mg of fosaprepitant meglumine is equivalent to about 115 mg of fosaprepitant.
A dose of fosaprepitant meglumine equivalent to 115 mg fosaprepitant may be given intravenously instead of oral aprepitant, with a corticosteroid and a 5-HT3 antagonist (for details, see Administration, under Aprepitant). The reconstituted dose of fosaprepitant is diluted in llOmL of sodium chloride 0.9% to a final concentration of 1 mg/mL and infused over 15 minutes.
Proprietary Preparations
Czech Republic: Ivemend
Portugal: Ivemend
United Kingdom: Ivemend
USA: Emend.
Ginger
Drug Nomenclature
Synonyms: Gengibre; Gingembre; Gyömbér gyökértörzs; Imbierų šakniastiebiai; Ingefära; Ingwer; Inkivääri; Jengibre; Zázvorový oddenek; Zingib.; Zingiber; Zingiberis RhizomaPharmacopoeias. In China, Europe, Japan, and US. US also includes the powdered form.
European Pharmacopoeia, 6th ed. (Ginger). The dried, whole or cut rhizome of Zingiber officinale, with the cork removed, either completely or from the wide flat surfaces only. Whole or cut, it contains not less than 1.5% of essential oil, calculated with reference to the anhydrous drug. It has a characteristic aromatic odour. Protect from light.
The BP 2008 states that ginger may be known in commerce as unbleached ginger.
The United States Pharmacopeia 31, 2008 (Ginger). The scraped, partially scraped, or unscraped rhizome of Zingiber officinale (Zingiberaceae), known in commerce as unbleached ginger. It contains not less than 4.5% of alcohol-soluble extractive and not less than 10% of water-soluble extractive. Store at 8° to 15°. Protect from light and moisture.
Drug Profile
Ginger has carminative properties. It is used as a flavouring agent and has been tried for the prophylaxis of motion sickness and nausea and vomiting in pregnancy, although it does not seem to be effective for postoperative nausea and vomiting.
Ginger oil is used in aromatherapy.
Homoeopathy
Ginger has been used in homoeopathic medicines under the following names: Zingiber Zingiber officinale Zing.
Preparations
BP 2008: Aromatic Cardamom Tincture; Strong Ginger Tincture; Weak Ginger Tincture
The United States Pharmacopeia 31, 2008: Ginger Capsules; Ginger Tincture.
Proprietary Preparations
Australia: Travacalm Natural
Canada: Gravol Natural Source
Germany: Zinto-na
Switzerland: Zintona
Thailand: Zinaxin
UK: Travel Sickness; Zinaxin.
Multi-ingredient
Australia: Bioglan Ginger-Vite Forte Bioglan Psylli-Nucil Plus Boswellia Complex Boswellia Compound Broncafect Cal Alkyline Diaco Digestive Aid Dyzco Extralife Arthri-Care Feminine Herbal Complex Ginkgo Plus Herbal Plus Formula I Of Herbal Cleanse Herbal Digestive Formula Lifesystem Herbal Plus Formula II Ginkgo PC Regulax Peritone PNS Support PNT Complex Travelaide
Austria: Nariazeller
Brazil: Broncol Tussifen
Canada: Cayenne Plusf Chase Kolik Gripe Water
Czech Republic: Klosterfrau Nelisana Naturland Grosser Swedenbitter
France: Arthrolib Evacrine
Germany: Fovysat Gallexier Gastricard Gastrosecur Gastrysat JuVitorr Najocarmin forte Presselin Dyspeptikum Unex Amarum
Hong Kong: Nagesto
India: Carmicide Happy’tizer Papytazyme Tummy Ease Well-Beeing
Indonesia: Avogin Pectum Pregnasea
Italy: Donalg Lozione Same Urto Pik Gel
Malaysia: Dandelion Complex Strepsils Cough Lozenge Strepsils Cough Syrup Total Marr Zinaxin Plus
Philippines: Bo-D-Fense Ruflex
Poland: Nelisana Klosterfrau
Russia: Dipana (Дипана); Doktor Mom (Доктор Мом); Doktor Mom Herbal Cough Lozenges (Доктор Мом Растительные Пастилки От Кашля); Maraslavin (Мараславин); Original Grosser Bittner Balsam (Оригинальный Большой Бальзам Биттнера); Suprima-Broncho (Суприма-бронхо);
South Africa: Hel-montskruie Lewensessens Wonderkroonessens
Singapore: Artrex
Switzerland: Padma-Lax Padmed Laxan Tisane pour les problemes de prostate
Thailand: Carmicide Flatulence Magesto Mesto-O Papytazyme Zinaxin Plus
United Kingdom: Arheumacare Digestive HRI Golden Seal Digestive; Indian Brandee Indigestion Reliet Neo Baby Gripe Mixture Neo Gripe Mixture Traveleeze Wind & Dyspepsia Reliet Zinopin
Venezuela: Ervossil Jengimiel Jengimiel Sabila
Indisetron Dihydrochloride
Drug Nomenclature
Drug Profile
Indisetron is a 5-HT3-receptor antagonist with general properties similar to those of ondansetron it is also stated to be an antagonist at 5-HT4 receptors. Indisetron hydrochloride is used as an antiemetic in the management of nausea and vomiting associated with chemotherapy.
Itopride Hydrochloride
Drug Nomenclature
Drug profile
Itopride hydrochloride is a substituted benzamide with general properties similar to those of metoclopramide that has been used for its prokinetic and antiemetic actions in oral doses of 50 mg three times daily before meals.
Proprietary Preparations
Czech Republic: Ganaton
India: Itoprid
Japan: Ganaton
Malaysia: Ganaton.
Mecloxamine Citrate
Drug Nomenclature
Drug profile
Mecloxamine citrate is reported to have antimuscarinic properties and has been used for its antiemetic action in antimigraine preparations.
Preparations – Multi-ingredient
Austria: Avamigran
Turkey: Avmigran.
Metopimazine
Drug Approvals
(British Approved Name, US Adopted Name, rINN)
INNs in other languages (French, Latin, and Spanish):
Pharmacopoeias. In France.
Drug profile
Metopimazine, a phenothiazine dopamine antagonist, is an antiemetic with general properties similar to those of chlorpromazine. It is used in the management of nausea and vomiting, including that associated with cancer chemotherapy. It is given in usual oral doses of 15 to 30 mg daily, in 2 to 4 divided doses similar daily doses have been given by rectum in 3 divided doses. It has also been given by injection in a dose of 10 to 20 mg daily, usually intramuscularly but occasionally by the intravenous route. Higher doses of 30 to 50 mg daily by intramuscular injection or intravenous infusion have been given for chemotherapy-induced nausea and vomiting.
Proprietary Preparations
Denmark: Vogalene
France: Vogalene Vogalib.
Ramosetron Hydrochloride
Drug Nomenclature
Drug profile
Ramosetron is a 5-HT3 antagonist with general properties similar to those of ondansetron. Ramosetron hydrochloride is given for its antiemetic properties in the management of nausea and vomiting induced by cancer chemotherapy in usual doses of 300 micrograms once daily intravenously, or 100 micrograms once daily by mouth. Ramosetron is also under investigation in the management of diarrhea-predominant irritable bowel syndrome.
Proprietary Preparations
Indonesia: Nasea
Japan: Nasea
Philippines: Nasea
Thailand: Nasea
Jennifer is a clinical pharmacologist. She helps doctors of all medical specialties choose medications. Jennifer consults about drug dosage, interactions, and side effects.