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GI Drugs: Antacids

Alexitol Sodium

Alexitol SodiumDrug Approvals

(British Approved Name, rINN)

BAN: Alexitol Sodium
INN: Alexitol Sodium [rINN (en)]
INN: Alexitol sódico [rINN (es)]
INN: Alexitol Sodique [rINN (fr)]
INN: Alexitolum Natricum [rINN (la)]
INN: Алекситол Натрий [rINN (ru)]
Chemical name: Sodium poly(hydroxyaluminium) carbonate-hexitol complex
CAS: 66813-51-2

Profile

Alexitol sodium is an antacid with general properties similar to those of aluminium hydroxide. It is given orally in doses of 360 to 720 mg when required, up to a maximum of sixteen 360-mg tablets in 24 hours.

Preparations

Proprietary Preparations

Hong Kong: Actal

Malaysia: Actal

Singapore: Actal

Thailand: Actal

UK: Actal.

Multi-ingredient

Malaysia: Actal Plus

Almagate

AlmagateDrug Approvals

(British Approved Name, US Adopted Name, rINN)

Synonyms: Almagát; Almagaatti; Almagat; Almagatas; Almagato; Almagatum; LAS-3876
BAN: Almagate
USAN: Almagate
INN: Almagate [rINN (en)]
INN: Almagato [rINN (es)]
INN: Almagate [rINN (fr)]
INN: Almagatum [rINN (la)]
INN: Альмагат [rINN (ru)]
Chemical name: Aluminium trimagnesium carbonate heptahydroxide dihydrate
Molecular formula: AlMg3(CO3)(OH)7,2H2O =315.0
CAS: 66827-12-1 (almagate); 72526-11-5 (anhydrous almagate)
ATC code: A02AD03

Pharmacopoeias. In Europe.

European Pharmacopoeia, 6th ed. (Almagate). A white or almost white, fine crystalline powder. It contains 15.0 to 17.0% aluminium calculated as aluminium oxide, 36.0 to 40.0% magnesium calculated as magnesium oxide, and 12.5 to 14.5% carbonic acid calculated as carbon dioxide. Practically insoluble in water, in alcohol, and in dichloromethane. It dissolves with effervescence and heating in dilute mineral acids. The filtrate of a 4% suspension in water has a pH of 9.1 to 9.7. Store in airtight containers.

Profile

Almagate is a hydrated aluminium-magnesium hydroxycarbonate. It is an antacid with general properties similar to those of aluminium hydroxide and magnesium carbonate. It is given orally in doses of 1 to 1.5 g.

Proprietary Preparations

 

Mexico: Almax

Spain: Almax Deprece Obetine.

Almasilate

Drug Approvals

(British Approved Name, rINN)

International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish):

Synonyms: Almasilato; Aluminium Magnesium Silicate Hydrate; Magnesium Aluminosilicate Hydrate; Magnesium Aluminum Silicate Hydrate
BAN: Almasilate
INN: Almasilate [rINN (en)]
INN: Almasilato [rINN (es)]
INN: Almasilate [rINN (fr)]
INN: Almasilatum [rINN (la)]
INN: Алмазилат [rINN (ru)]
Molecular formula: Al2O3.MgO.2SiO2,xH2O =262.4 (anhydrous)
CAS: 71205-22-6; 50958-44-6
ATC code: A02AD05

Profile

Almasilate is an artificial form of aluminium magnesium silicate hydrate. It is an antacid that is given orally in doses of up to about 1 g.

A hydrated native aluminium magnesium silicate is used as a suspending, thickening, and stabilising agent in pharmaceutical preparations. Attapulgite is another native form.

Preparations

Proprietary Preparations

Austria: Gelusil

Germany: Gelusil; Megalac; Simagel

Spain: Alubifar

 

Multi-ingredient

Austria: Gastripan

Germany: Gelusil-Lac; Neo-Pyodron N; Ultilac N

India: Entasid

Spain: Dolcopin

Switzerland: Gelusil N.

Aloglutamol

Drug Nomenclature

Chemical name: 2-Amino-2-hydroxymethylpropane-1,3-diol gluconate dihydroxyaluminate
Molecular formula: C10H24AlNO12 =377.3
ATC code: A02AB06

Profile

Aloglutamol has been used as an antacid.

Proprietary Preparations

Mexico: Sabro.

Hydrotalcite

Drug Nomenclature

Synonyms: Hidrotalcita; Hydrotalcit; Hydrotalcitum; Hydrotalsiitti
BAN: Hydrotalcite
INN: Hydrotalcite [rINN (en)]
INN: Hidrotalcita [rINN (es)]
INN: Hydrotalcite [rINN (fr)]
INN: Hydrotalcitum [rINN (la)]
INN: Гидроталцит [rINN (ru)]
Chemical name: Aluminium magnesium carbonate hydroxide hydrate
Molecular formula: Mg6Al2(OH)16CO3,4H2O =604.0
CAS: 12304-65-3
ATC code: A02AD04
Read code: y03Ln

Note. Compounded preparations of hydrotalcite may be represented by the following names:

• Co-simalcite x/y (BAN) — where x and y are the strengths in milligrams of simeticone and hydrotalcite respectively.

Pharmacopoeias. In British.

BP2008 (Hydrotalcite). A hydrated form of an aluminium magnesium basic carbonate corresponding to the formula Al2Mg6(OH)16CO3,4H2O. It contains not less than 15.3% and not more than 18.7% of Al2O3 and not less than 36.0% and not more than 44.0% of MgO. The ratio of Al2O3 to MgO is not less than 0.40 and not more than 0.45. A white or almost white, free-flowing, granular powder. Practically insoluble in water it dissolves in dilute mineral acids with slight effervescence. A 4% suspension in water has apH of 8.0 to 10.0.

Profile

Hydrotalcite is an antacid that is given in oral doses of up to about 1 g.

Preparations

BP 2008: Hydrotalcite Tablets.

Proprietary Preparations

Austria: Talcid; Talidat

Czech Republic: Rutacid; Talcid; Talidat

Germany: Ancid; Megalac; Talcid; Talidat

Greece: Talcid

Hungary: Talcid; Tisacid

Israel: Talcid

Malaysia: Swecon

Mexico: Talcid

The Netherlands: Talcid; Talidat; Ultacit

Poland: Malgacid; Rutacid; Talcid; Ulcetal

Portugal: Talidat

Russia: Rutacid; Talcid

South Africa: Altacite

Spain: Talcid

Turkey: Talcid

Venezuela: Baytalcid .

Multi-ingredient

Indonesia: Promag

Japan: Eki Cabe

Philippines: Sinneco

United Kingdom: Altacite Plus.

Magaldrate

Drug Approvals

(British Approved Name, US Adopted Name, rINN)

INNs in other languages (French, Latin, and Spanish):

Synonyms: AY-5710; Aluminum Magnesium Hydroxide Sulfate; Magaldrát; Magaldraatti; Magaldrat; Magaldratas; Magaldrato; Magaldratum
BAN: Magaldrate
USAN: Magaldrate
INN: Magaldrate [rINN (en)]
INN: Magaldrato [rINNM (es)]
INN: Magaldrate [rINNM (fr)]
INN: Magaldratum [rINNM (la)]
INN: Магальдрат [rINNM (ru)]
Molecular formula: Al5Mg10(OH)31(SO4)2,xH2O =1097.3 (anhydrous)
CAS: 74978-16-8
ATC code: A02AD02
Read code: y03Lo

Note. Magaldrate was formerly described as Aluminium Magnesium Hydroxide (AlMg2(OH)7 monohydrate, CAS 1317-26-6).

Pharmacopoeias. In Europe and US.

European Pharmacopoeia, 6th ed. (Magaldrate). A combination of aluminium and magnesium hydroxides and sulfates. It contains the equivalent of 90 to 105% of Al5Mg10(OH)31(SO4)2, calculated with reference to the dried substance. A white or almost white crystalline powder. Practically insoluble in water and in alcohol soluble in dilute mineral acids. It loses between 10 and 20% of its weight on drying at 200° for 4 hours.

The United States Pharmacopeia 31, 2008 (Magaldrate). A combination of aluminium and magnesium hydroxides and sulfates. It contains the equivalent of 90 to 105% of Al5Mg10(OH)31(SO4)2, calculated on the dried basis. A white odourless crystalline powder. Insoluble in water and in alcohol soluble in dilute solutions of mineral acids. It loses between 10 and 20% of its weight on drying at 200° for 4 hours.

Profile

Magaldrate is an antacid that is given in oral doses of up to about 2 g.

Preparations

British Pharmacopoeia 2008: Magaldrate Oral Suspension

The United States Pharmacopeia 31, 2008: Magaldrate and Simethicone Oral Suspension; Magaldrate and Simethicone Tablets; Magaldrate Oral Suspension; Magaldrate Tablets.

Proprietary Preparations

Argentina: Riopan

Austria: Riopan

Belgium: Gastricalm Riopan

Brazil: Riopan

Czech Republic: Marax

France: Riopan

Germany: Gastripan Gastrostacl Glysan Hevert-Mag Magastron Marax Riopan Simaphil

Greece: Felfar Riopan

Italy: Gadral Magaltop Magralibi Riopan

Poland: Malugastrin

Portugal: Riopan

Russia: Magalphil

South Africa: Riopone

Spain: Bemolan Gastromol Magion Minoton

Switzerland: Riopan

USA: losopan Riopan

Venezuela: Cremag.

Multi-ingredient

Argentina: Aci-Tip Carbogasol Antiacido

Australia: Mylanta Heartburn Relief

Brazil: Riopan Plus

Chile: Aci-Tip Antiax

Hong Kong: Nilcid-MPS

India: Maglid pH4 Rolac Plus Ulgel

Indonesia: Asidrat Magalat Nudramag

Mexico: Nilcidf Riopan

Spain: Compagel

Turkey: Asidopan Plus Simelgat Plus

UK: Bisodol Extra Bisodol Heartburn Relief

USA: losopan Plus Lowsium Plus Riopan Plus

Venezuela: Cremalon.

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