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Metoclopramide Injection BP (Metoclopramide Hydrochloride)

Last updated on: October 8, 2021

Metoclopramide Injection BP 10mg/2ml. (Metoclopramide Hydrochloride)

Metoclopramide Injection BP (Metoclopramide Hydrochloride)About your medicine

Metoclopramide Injection BP is a clear, colourless, sterile solution for injection in 2ml clear glass ampoules.

Active ingredient: Each 2ml of sterile solution for injection contains metoclopramide hydrochloride equivalent to 1 Omg of anhydrous metoclopramide hydrochloride.

Inactive ingredients: Sodium Metabisulphite (E223), sodium chloride and hydrochloric acid or sodium hydroxide in water for injections.

Pack sizes: 10 x 2ml ampoules.

How does metoc/opramide worlc: Metoclopramide works on the muscles in the upper part of your digestive system. This helps your digestive system to work properly. It can also stop you from feeling sick (nausea) or from being sick (vomiting).


Metoclopramide Injection may be used

  • to relieve symptoms in the upper part of your digestive system, including stomach discomfort after eating, belching or too much wind, heartburn, nausea and pain which may occur with conditions such as: peptic ulcer, inflammation of the gullet caused by acid from the stomach, inflammation of the stomach or the adjacent small bowel, gallstones, hiatus hernia or following an operation to remove your gall bladder
  • for the treatment of nausea and vomiting associated with: disorders of the stomach or intestine, cytotoxic drugs (these are used to treat various conditions including psoriasis, some types of cancer and arthritis), heart failure, migraine, radiotherapy, or vomiting after an anaesthetic
  • to help the stomach to empty normally and the upper part of your digestive system to move properly after a stomach operation
  • for certain diagnostic tests in the digestive system: to help during a barium meal examination or during the passing of a tube into the stomach or intestine.

For patients under 20 years of age, Metoclopramide Injection BP should only be used in the following conditions:

  • severe persistent vomiting, where the cause is known
  • vomiting associated with radiotherapy and cytotoxic drugs
  • to help in passing a tube into the stomach or intestine
  • as part of a premedication (a medicine given before an operationj.

Metoclopramide Injection BP (Metoclopramide Hydrochloride)Before you receive your medicine

  • you should not receive this injection if you have had an allergic reaction to Metoclopramide or to any of the other ingredients,
  • you suffer from high blood pressure due to a tumour near the kidney (a condition known as phaeochromocytoma)
  • you had an operation on the stomach or intestine within the previous 4 days
  • you have been told by a doctor that you have bleeding, blockage, perforation or ulcers of the stomach or intestines. Before you receive this injection, tell your doctor if
  • you have a problem with your liver or kidneys
  • you are pregnant or if you are breast feeding

Are you taking pain killers such as aspirin, paracetamol or stronger painkillers called opioids?

Are you taking a medicine called atovaquone to treat pneumonia?

Are you taking immunosuppressants like ciclosporins?

Are you taking any other medicine by mouth? It is possible that metoclopramide injection may change the amount of the other medicine that gets into your body.

Are you taking any drugs known as serotonergic drugs? You should tell your doctor as taking these medications with metoclopramide injection can cause side effects (such as restlessness, loss of coordination, fast heart beat increased body temperature) you are taking any other medicines, including

  • anticholinergic drugs (e.g. for a stomach or intestine problem, or for Parkinson’s disease, or for a “weak bladder’, or as an inhaler for a breathing problem)
  • medicine for epilepsy, or any other medicine that acts on the brain or spinal cord
  • a neuroleptic drug (e.g. for a mental illness, or for nausea or vomiting)

Do you suffer from porphyria (a rare inherited blood disease)? Driving or operating machinery: Rarely, metoclopramide may cause drowsiness which could interfere with your ability to drive or to use machines safely. If you notice any drowsiness, do not drive or use machinery. Ask your doctor for advice.

Persistent vomiting: If you are receiving this medicine for vomiting and if the vomiting does not stop, tell your doctor.

This medicinal product contains less than 1 mmol (23mg) sodium per dose i.e essentially ‘sodium-free’.

Sodium metabisulphite, one of the excipients, may rarely cause severe hypersensitivity reactions and bronchospasm.

How your medicine is administered

Metoclopramide Injection BP may be given by injection into a muscle. It may also be given by slow injection into a vein over a period of 1 to 2 minutes. To avoid unwanted effects, the dosage recommendations shown below should be followed strictly. The total dosage of metoclopramide per day should not normally exceed 0.5mg per kilogram of body weight; this is especially important in the case of children or young adults. Your doctor will choose the most suitable dose to meet your requirements. If your kidneys or liver are not working properly, your doctor may want to give you a reduced dosage.

Dosage for relief of symptoms

Adults age 20 years and over: 10 mg three times daily.

For patients of less than 60kg of body weight, see below.

Elderly patients: 10mg   three   times   daily.   To   avoid unwanted effects, the dosage recommendations should be followed carefully. If you are receiving a prolonged course of treatment, your doctor may want to check you regularly.

Young adults and children: Your doctor may want to examine you before you receive your injection. To avoid unwanted effects, the dosage recommendations should be followed carefully and treatment should commence at the lower dosage where stated:

Young adults 15-19 years: 60kg body weight and over;10 mg three times daily.

Young adults 15-19 years: 30 to 59kg body weight; 5mg three times daily.

Children 9-14 years: 30kg body weight and over; 5mg three times daily.

Children 5-9 years: 20 to 29kg body weight; 2.5mg three times daily.

Children 3-5 years: 15-19kg body weight; 2mg two to three times daily.

Children 1-3 years: 10 to 14kg body weight; 1mg two to three times daily.

Children under 1 year: up to 10kg body weight; 1 mg twice daily.

Dosage for diagnostic tests

A single dose of metoclopramide may be given 5 to 1 0 minutes before the examination. When deciding on the dosage, your doctor will take into account the information provided above about body weight. If you have sufficient body weight, the following dosages are recommended:

Adults aged 20 years and over: 10to20mg.
Young adults aged 15 to 19 years: 10 mg
Children: aged 9-14 years: 5mg.
aged 5-9 years: 2.5mg.
aged 3-5 years: 2mg.
under 3 years: 1 mg.

Your doctor may give you a different dose if you have special needs.

The interval between doses may be longer in patients with kidney or liver problems.

If you still feel unwell at the end of your course of treatment, tell your doctor. If you continue to vomit (be sick) tell your doctor.

What to do in case of a missed dose or an overdose:

Since this injection will be given to you by a doctor or nurse it is unlikely that you will miss a dose or that you will be given too much. However, if you are worried that you have missed a dose or that you have been given too much, talk to the doctor or nurse looking after you.

After you receive your medicine

As well as having beneficial effects, a medicine may sometimes cause unwanted effects in some patients. There can be sudden rise in blood pressure in patients with a tumour of the adrenal gland (pheochromocytoma).

If you notice any of the following effects after you receive this injection, tell your doctor:

  • spasm of the face or jaw muscles
  • poking movements of the tongue, or problems with your speech
  • eyes becoming fixed in one position
  • unnatural positions of the head and shoulders, or arching of the back
  • increased muscle tension
  • odd repeated movements of the tongue, face, mouth or jaw, or of the arms and legs
  • drowsiness, restlessness, confusion or depression
  • diarrhoea
  • faintness
  • restless and distressed,
  • anxious or confused
  • swelling of the tongue
  • skin rashes
  • constipation
  • reduced sexual potency
  • hypotension
  • may induce possible acute hypertensive response in phaeochromocytoma
  • production of breast milk, enlargement of breast glands (in men), absent or lighter menstrual periods.

Severe allergic reactions can occur very rarely and usually happens soon after taking this medicine. These can involve difficulty in breathing, tightness in the throat, rapidly spreading rashes, dizziness, very fast heart beat, headache or even loss of consciousness. Extremely rarely the lips, nail beds and ears may look blue. If you notice any unwanted effects that are not mentioned here, tell your doctor.

Storing this medicine

Do not use this medicine after the expiry date printed on the label and carton.

Do not store above 25 °C.

Keep the container in the outer carton in order to protect from light.

Keep out of the reach and sight of children.

If only part used, discard the remaining solution.

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