Thioridazine (Mellaril) in stock
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Other names of Mellaril
Aldazine, Calmaril, Dazine-P, Ridazine, Thiomed, Thiosia, Dazithin, Detril, Elperil, Mallorol, Meleril, Mellerette, Melleretten, Melleril, Mellerettes, Melzine, Thiozine, Nervosan, Simultan, Tinsenol, Novo-Ridazine, Orsanil, Ridazin, Rideril, Sonapax, Thiodazine, Thioril, Tison, Thioril, Unitidazin.
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Table 4 Prescribing Information for Thioridazine (Mellaril ®) | ||
Optimum Dosage 1-3 mg/kg/day 20-200 mg/day Not recommended under 2 years of age Starting dose 10-25 mg b.i.d. |
Drug Interactions CNS depressants Antacids decrease absorption Anticholinergics Anticonvulsants increase risk of seizures Epinephrine increases hypotension Guanethidine |
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Minor Side-Effectsa Anticholinergic effects (>30%) Orthostatic hypotension (10%-30%) Drowsiness, sedation, lethargy (10%-30%) Amenorrhea and inhibition of ejaculation (10%-30%) Tachycardia (2%-10%) Photosensitivity and skin pigmentation (2%-10%) Weight gain (10%-30%) Gastrointestinal distressc Nasal stuffinessc Breast enlargement and galactorrheac Peripheral edemac Parotid swellingc |
Contra-indications Hypersensitivity to other phenothiazines History of blood dyscrasias Do not use in “pure” attention deficit disorders, because of decrease in learning curve |
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Drug Withdrawal Effects Tardive and withdrawal dyskinesia following long-term usage (>3-6 months) particularly in non-responders to treatment Rebound behavioural phenomenon Gastrointestinal distress Insomnia, restlessness, irritability Chills and cold sweats Common practice to decrease over 1 month to minimize above phenomena |
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Major Side-Effects Parkinsonism (2%-10%)b Akathisia(2%-10%)b Dystonic reactions (<2%)b Cardiac arrhythmias (10%-30%)b ECG abnormalities without cardiac injury (>30%) Pigmentary retinopathy (10%-30%) after chronic therapy Obstructive jaundice (<2%) Blood dyscrasia (2%-10%) within 1-3 months Dulling of intellectual performance0 Epileptic seizures (<2%)b |
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Concurrent Treatment and Alternatives
When used as a non-specific tranquilizer, the medication should be used in conjunction with one or more of the following: Behaviour therapy Family or caretaker therapy Residential treatment Remedial education Other psychotherapies |
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a. Frequencies from Bezchilibnyk-Butler and Jeffries.b. Dose related.
c. Rare. |