Sex hormones and modulators

Ethinylestradiol

A white to slightly yellowish-white, crystalline powder. Practically insoluble in water freely soluble in alcohol dissolves in dilute alkaline solutions. A white to creamy white, odourless, crystalline powder.

Chorionic Gonadotrophin

A dry preparation of placental glycoproteins extracted from the urine of pregnant women. The potency is not less than 2500 units/mg. A white to yellowish-white, amorphous powder.

Etonogestrel

As for progestogens in general (see Progesterone). See also under Hormonal Contraceptives. Etonogestrel was found in the breast milk of 42 women given a contraceptive etonogestrel implant.

Gonadorelin

A white to slightly yellowish powder. Soluble in water sparingly soluble in methyl alcohol.

Conjugated Oestrogens

A mixture of various conjugated forms of oestrogens obtained from the urine of pregnant mares or by synthesis, dispersed in a suitable powdered diluent. It contains two principal components, 52.5 to 61.5% of sodium estrone sulfate and 22.5 to 30.5% of sodium equilin sulfate the total of the combined two is 79.5 to 88.0%. It also contains 2.5 to 9.5% of sodium 17a-estradiol sulfate, 13.5 to 19.5% of sodium 17a-dihydroequilin sulfate, and 0.5 to 4.0% of sodium 17p-dihy-droequilin sulfate.

Clomifene Citrate

Clomifene may be separated into its Z- and IT-isomers, zu-clomifene and enclomifene. A white or pale yellow, crystalline powder.

Luteinising Hormone

These gonadotrophins stimulate the normal functioning of the gonads and the secretion of sex hormones in both men and women. In women, follicle-stimulating hormone stimulates the development and maturation of the follicles and ova.

Estradiol

Practically insoluble in water sparingly soluble in alcohol soluble in acetone slightly soluble in dichloromethane. White or creamy-white, odourless, hygroscopic small crystals or crystalline powder.

Goserelin

A nonapeptide analogue of the hypothalamic decapeptide, gonadorelin. It is obtained by chemical synthesis and is available as an acetate.

Hydroxyprogesterone Caproate

A white or creamy-white, crystalline powder. Odourless or having a slight odour.

Abarelix

Immediate hypersensitivity reactions, including urticaria, pruritus, hypotension, and syncope, can occur with abarelix, and the cumulative risk of such a reaction increases with repeated doses. Patients should be monitored for at least 30 minutes after each injection.

Dienestrol

Practically insoluble in water freely soluble in alcohol and in acetone dissolves in dilute solutions of alkali hydroxides. Colourless, white, or practically white needle-like crystals, or white or practically white crystalline powder.

Danazol

A white to pale yellow crystalline powder. Practically insoluble or insoluble in water and in petroleum spirit sparingly soluble in alcohol and in benzene soluble in acetone freely soluble in chloroform slightly soluble in ether.

Buserelin

A white or slightly yellowish hygroscopic powder. Sparingly soluble in water and in dilute acids. Protect from light and moisture.

Medroxyprogesterone Acetate

Practically insoluble in water sparingly soluble in alcohol soluble in acetone freely soluble in dichloromethane. A white to off-white, odourless, crystalline powder. Insoluble in water sparingly soluble in alcohol and in methyl alcohol soluble in acetone and in dioxan freely soluble in chloroform slightly soluble in ether.

Diethylstilbestrol

Practically insoluble in water freely soluble in alcohol dissolves in solutions of alkali hydroxides. A white, odourless, crystalline powder.

Chlormadinone Acetate

As for progestogens in general (see Progesterone). See also under Hormonal Contraceptives.

Norethisterone

A white or yellowish-white crystalline powder. Practically insoluble in water sparingly soluble in dehydrated alcohol and in acetone soluble in dichlorometh-ane. A white to creamy-white odourless crystalline powder.

Desogestrel

Practically insoluble in water freely soluble in dehydrated alcohol and in dichloromethane very soluble in methyl alcohol. As for progestogens in general (see Progesterone).

Fosfestrol

An off-white, odourless, crystalline powder. Sparingly soluble in water soluble in alcohol and in dilute alkali.