Drug Approvals
(BANM, US Adopted Name, rINNM)
International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish): Acetato de clormadinona; Chlormadinone, Acetate de; Chlormadinoni Acetas; NSC-92338.
6-Chloro-17-hydroxypregna-4,6-diene-3,20-dione acetate.
CAS — 1961-77-9 (chlormadinone); 302-22-7 (chlormadinone acetate).
ATC — C03DB06
Pharmacopoeias. In China, France, and Japan.
Adverse Effects and Precautions
As for progestogens in general (see Progesterone). See also under Hormonal Contraceptives.
Effects on the skin
A report of auto-immune dermatitis in a patient associated with chlormadinone acetate.
Interactions
As for progestogens in general (see Progesterone). See also under Hormonal Contraceptives.
Uses and Administration
Chlormadinone acetate is a progestogen structurally related to progesterone that has anti-androgenic activity. It is given either alone or with an oestrogen in the treatment of menstrual disorders such as menorrhagia and endometriosis in oral doses of 2 to 10 mg daily either cyclically or continuously. It may also be used as the progestogen component of combined oral contraceptives at a dose of 1 to 2 mg daily, particularly in women with androgen-dependent conditions such as acne and hirsutism. Chlormadinone acetate has been used in some countries in the management of prostatic hyperplasia and prostate cancer oral doses of 25 or 50 mg, respectively have been given twice daily.
Preparations
Proprietary Preparations
France: Luteran
Germany: Gestafortin
Japan: Prostal
Mexico: Lutoral.
Multi-ingredient
Chile: Belara Lovinda
Czech Republic: Belara
France: Belara
Germany: Balanca Belara Esticia Gestamestrol N Neo-Eunomin Ovosistoin
Hungary: Belara
Israel: Belara
Italy: Belara
Mexico: Belara Lutoral-E Secuentex-21
Portugal: Belara Libeli
Russia: Belara
Spain: Belara
Switzerland: Belara
Venezuela: Belara.
Jennifer is a clinical pharmacologist. She helps doctors of all medical specialties choose medications. Jennifer consults about drug dosage, interactions, and side effects.