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Chlormadinone Acetate

Chlormadinone AcetateDrug Approvals

(BANM, US Adopted Name, rINNM)

International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish): Acetato de clormadinona; Chlormadinone, Acetate de; Chlormadinoni Acetas; NSC-92338.

6-Chloro-17-hydroxypregna-4,6-diene-3,20-dione acetate.

CAS 1961-77-9 (chlormadinone); 302-22-7 (chlormadinone acetate).

ATC C03DB06

Pharmacopoeias. In China, France, and Japan.

Adverse Effects and Precautions

As for progestogens in general (see Progesterone). See also under Hormonal Contraceptives.

Effects on the skin. A report of auto-immune dermatitis in a patient associated with chlormadinone acetate.

 

Interactions

As for progestogens in general (see Progesterone). See also under Hormonal Contraceptives.

Uses and Administration

Chlormadinone acetate is a progestogen structurally related to progesterone that has anti-androgenic activity. It is given either alone or with an oestrogen in the treatment of menstrual disorders such as menorrhagia and endometriosis in oral doses of 2 to 10 mg daily either cyclically or continuously. It may also be used as the progestogen component of combined oral contraceptives at a dose of 1 to 2 mg daily, particularly in women with androgen-dependent conditions such as acne and hirsutism. Chlormadinone acetate has been used in some countries in the management of prostatic hyperplasia and prostate cancer oral doses of 25 or 50 mg, respectively have been given twice daily.

Preparations

Proprietary Preparations

France: Luteran

Germany: Gestafortin

Japan: Prostal

Mexico: Lutoral.

Multi-ingredient

Chile: Belara Lovinda

Czech Republic: Belara

France: Belara

Germany: Balanca Belara Esticia Gestamestrol N Neo-Eunomin Ovosistoin

Hungary: Belara

Israel: Belara

Italy: Belara

Mexico: Belara Lutoral-E Secuentex-21

Portugal: Belara Libeli

Russia: Belara

Spain: Belara

Switzerland: Belara

Venezuela: Belara.

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