Duphaston (Dydrogesterone)

Duphaston
4.323 ratingsReviews
Generic:
Dydrogesterone
Indications:
endometriosis infertility premenstrual syndrome
Analogs:
Dydrogesterone Utrogestan Prometrium Medroxyprogesterone Acetate Provera Norethisterone Primolut N Dienogest Visanne Femoston Orgametril Crinone Cyclogest Progesterone
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Duphaston 10 mg

Quantity Price per tablet You save Total price
20 $7.25 - $145.00
30 $6.37 $26.50 $191.00
60 $5.20 $123.00 $312.00
90 $4.92 $209.50 $443.00
120 $4.54 $325.00 $545.00
180 $4.42 $510.00 $795.00
270 $4.24 $811.50 $1,146.00
360 $4.08 $1,140.00 $1,470.00

Manufacturers

Abbott Biologicals B.V.Solvay Pharmaceuticals, Inc.

Payment & Shipping

Package Example

Your order is carefully packed and ships within 24 hours. Here's the typical package.

Sized like a regular personal letter (9.4x4.3x0.3 inches), with no indication of its contents.

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Shipping Times
Shipping MethodEstimated delivery
Express Free for orders over $300.00Estimated delivery to the U.S.: 4-7 days
Standard Free for orders over $200.00Estimated delivery to the U.S.: 14-21 days
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Discount Coupons

  • Independence Day - July 4, 2026 10% JULY410
  • Labor Day - September 7, 2026 7% LABOR07
  • Thanksgiving - November 26, 2026 9% THANKS09

FAQ

Yes. Tell the surgeon, dentist, anesthesiologist, or other treating clinician that you take dydrogesterone, along with your dose and the reason it was prescribed. This is especially important if anticoagulants, clot-dissolving medicines, or other hormone treatments are involved. Do not stop or change the medicine before a procedure unless the clinician managing the procedure gives instructions.

This 10 mg film-coated tablet contains dydrogesterone. Duphaston is a brand name associated with dydrogesterone in some markets, but the exact manufacturer, tablet appearance, inactive ingredients, and packaging of the supplied product can vary. Compare the active ingredient, strength, and dosage form on the package when evaluating another product.

A different color, shape, or package does not by itself mean the medicine is wrong. Check the package label for dydrogesterone, the 10 mg strength, and film-coated tablet dosage form, then compare the manufacturer, lot number, expiration date, and tablet imprint if one is present. Do not use the tablets until the discrepancy is checked if the ingredient, strength, dosage form, imprint, seal, or physical condition appears wrong or compromised.

Dydrogesterone is a progestin used for conditions associated with progesterone deficiency. Established uses include certain menstrual disorders, such as irregular, absent, or painful periods; endometriosis; premenstrual symptoms; and infertility related to luteal-phase insufficiency. It may also be used in selected pregnancy-related situations under an obstetric treatment plan.

Description

DuphastonWhat Is Duphaston (Dydrogesterone)

Duphaston is a brand name for the medication dydrogesterone, a synthetic hormone in the progestin class. Progestins are synthetic forms of the hormone progesterone, which is naturally produced by the ovaries in women. 

Duphaston is primarily used in the treatment of various gynecological conditions. It is commonly prescribed to support pregnancy and prevent miscarriage in women with recurrent miscarriages or specific hormonal imbalances.

Dydrogesterone is often used as a form of progesterone replacement therapy. Progesterone plays a crucial role in preparing the uterine lining for the implantation of a fertilized egg and maintaining a healthy pregnancy.

Duphaston may also be prescribed to treat certain menstrual disorders, such as irregular periods, premenstrual syndrome (PMS), and dysmenorrhea (painful menstruation).

In some cases, Duphaston may be used to manage endometriosis, a condition where tissue similar to the lining of the uterus grows outside the uterus.

Duphaston is not typically used as a standalone hormone replacement therapy but may be combined with estrogen in hormone replacement therapy for postmenopausal women with an intact uterus.

Duphaston is usually taken orally in the form of tablets. The dosage and duration of treatment depend on the specific condition and the individual patient.

Common side effects of Duphaston may include nausea, breast tenderness, and changes in menstrual bleeding. Serious side effects are rare but can include allergic reactions or liver problems.

Duphaston is often prescribed during pregnancy to support the early stages of gestation. The safety of Duphaston during breastfeeding needs to be better established, and its use should be discussed with a healthcare provider.

It's crucial for individuals prescribed Duphaston to follow the recommended dosage and schedule provided by their healthcare provider. As with any medication, potential benefits and risks should be discussed with a healthcare professional, especially if there are concerns or underlying health conditions.

Uses and Administration

Dydrogesterone is a progestogen structurally related to progesterone. It does not have oestrogenic or androgenic properties.

Dydrogesterone has been given orally in the treatment of menstrual disorders such as menorrhagia, usually in a dose of 10 mg twice daily in a cyclical regimen, and for the treatment of endometriosis in a dose of 10 mg two or three times daily cyclically or continuously. It has also been given cyclically in doses of 10 mg once or twice daily or continuously in doses of 5 mg daily for endometrial protection during menopausal HRT.

In threatened miscarriage, suggested doses have been 40 mg initially followed by 10 mg or more every 8 hours, continued for a week after symptoms cease, then gradually reduced unless symptoms return. In recurrent miscarriage, suggested doses have been 10 mg twice daily, given cyclically until conception, then continuously until week 20 of pregnancy; the dose may then be gradually reduced. However, such use is only recommended if there is proven progesterone deficiency. Cyclical dydrogesterone has also been used in infertility in doses of 10 mg twice daily.

Adverse Effects and Precautions

Duphaston (dydrogesterone) may cause side effects, like any medication, in some individuals. It's important to note that not everyone will experience these side effects, and some people may experience none at all. Common side effects of Duphaston may include:

  1. Nausea: Some individuals may experience nausea as a common side effect of Duphaston. Taking the medication with food may help reduce this symptom.
  2. Breast Tenderness: Duphaston can cause breast tenderness or discomfort. This side effect is usually mild and temporary.
  3. Headache: Headaches have been reported as a side effect in some individuals taking Duphaston.
  4. Changes in Menstrual Bleeding: Duphaston is often prescribed to regulate menstrual cycles. However, it can sometimes cause changes in menstrual bleeding, including spotting or changes in flow.
  5. Skin Reactions: In rare cases, individuals may experience skin reactions such as rash or itching.
  6. Abdominal Pain: Some individuals may experience abdominal discomfort or pain as a side effect of Duphaston.
  7. Changes in Mood: Hormonal medications, including Duphaston, may affect mood in some individuals. Changes in mood, such as mood swings or irritability, have been reported.
  8. Allergic Reactions: Although rare, allergic reactions to Duphaston can occur. Signs of an allergic reaction may include rash, itching, swelling, severe dizziness, or difficulty breathing. Seek medical attention if you experience these symptoms.

It's essential to report any unusual or severe side effects to your healthcare provider promptly. Additionally, if you have a history of certain conditions, such as liver problems, you must inform your healthcare provider before starting Duphaston.

While the above list includes potential side effects, not everyone will experience them. Your healthcare provider can provide personalized information about the benefits and risks of Duphaston based on your specific health situation. Consult your healthcare provider for guidance if you have concerns about side effects or experience any unusual symptoms.

Porphyria

Dydrogesterone is associated with acute porphyria attacks and is considered unsafe in patients with porphyric.

Pregnancy

Anomalies (non-virilising) of the genito-urinary tract were found in a 4-month-old baby whose mother had taken dydrogesterone 20 mg daily from the eighth to twentieth week of pregnancy and 10 mg daily until the term. She was also given hydroxyprogesterone caproate 250 mg by intramuscular injection weekly from the eighth to the twentieth week.

Interactions

Dydrogesterone, the active ingredient in Duphaston, may interact with other medications and substances, potentially affecting their effectiveness or increasing the risk of side effects. You must inform your healthcare provider about all your medications, supplements, and over-the-counter drugs. Here are some potential interactions to be aware of:

  1. Estrogen-containing Medications: Duphaston is often used with estrogen in hormone replacement therapy (HRT) for postmenopausal women with an intact uterus. When used with estrogen, it may interact with certain medications, and the overall hormone replacement therapy regimen should be carefully monitored.
  2. Anticoagulants (Blood Thinners): Evidence suggests that dydrogesterone may enhance the anticoagulant effect of medications like warfarin. Close monitoring of blood clotting parameters is recommended if these medications are used together.
  3. Rifampin: Rifampin, an antibiotic used to treat tuberculosis, may decrease the effectiveness of dydrogesterone. Additional contraceptive measures may be needed if using both medications.
  4. Phenytoin: Phenytoin, an anticonvulsant, may decrease the effectiveness of dydrogesterone. Adjustments to the dosage of dydrogesterone may be necessary if used concurrently.
  5. Barbiturates: Barbiturates, such as phenobarbital, may decrease the effectiveness of dydrogesterone. Monitoring and potential adjustments in dosage may be needed.
  6. Herbal Supplements: St. John's Wort, an herbal supplement, may induce the metabolism of dydrogesterone, potentially reducing its effectiveness. It's advisable to inform your healthcare provider about herbal supplements.
  7. Grapefruit Juice: Grapefruit juice may interact with dydrogesterone by affecting its metabolism. It's advisable to avoid consuming grapefruit or grapefruit juice while taking Duphaston.
  8. Interactions with Other Hormonal Medications: Dydrogesterone may interact with other hormonal medications, and a healthcare provider should carefully monitor the use of multiple hormonal therapies.

This list is not exhaustive, and individual responses to medications can vary. Always provide a comprehensive list of your medications and supplements to your healthcare provider to ensure Duphaston's safe and effective use. They can help assess potential interactions and adjust your treatment plan accordingly.

Medically reviewed by
Jennifer Bowles
Pharmacologist
Updated August 11, 2026

Customer questions

Asked by Edward R, New York, United States

Can dydrogesterone tablets handle ordinary mail transportation, or do they need special cold shipping?

Answered by Support team

Film-coated tablets can normally travel by mail when they are packed to protect the original package and blister from crushing and moisture. Keep them in the original package and store them below 86°F after arrival. Because the actual temperatures and duration of transit can vary, check the package and tablets for damage before use.

Asked by Nicholas J, Philadelphia, United States

My order arrived in Philadelphia. Where on the package can I confirm I received the dydrogesterone strength I selected?

Answered by Support team

Check the outer carton and blister label for the active ingredient "dydrogesterone," the strength "10 mg," and "film-coated tablet" for oral use. Also compare the manufacturer, lot number, expiration date, and tablet imprint when present. Do not take the product if the labeled ingredient, strength, or dosage form does not match your order.

Asked by Andrew N, San Francisco, United States

The blister in my package looks partly torn after delivery. Can I still use the tablets that are inside it?

Answered by Support team

Do not use tablets from a blister or package whose seal or protective barrier appears damaged until the issue has been checked. Keep the carton, blister, and affected tablets so the product label, lot number, expiration date, and physical condition can be reviewed.

Asked by Amanda D, Austin, United States

Will the dydrogesterone package include an instruction leaflet in English?

Answered by Support team

The leaflet language for the supplied package cannot be confirmed in advance. Check the received carton and leaflet for the product-specific instructions, and verify the active ingredient, 10 mg strength, and oral film-coated tablet form on the package label.

Asked by William B, Chicago, United States

I am taking dydrogesterone for irregular cycles and just had a positive pregnancy test. Should I keep taking it?

Answered by Support team
Medical reviewed by Jennifer Bowles

Do not make a self-directed decision to stop, continue, or change the dose. Dydrogesterone may be used during pregnancy for specific obstetric indications, but whether it should be continued depends on why it was prescribed and the treatment plan; contact the clinician managing your pregnancy promptly for instructions.

Product specifications

Active ingredientDydrogesterone
Drug classProgestin
Dosage formFilm-coated tablet
Available strengths10 mg
RouteOral
StorageStore below 86°F in the original package.
ATC codeG03DB01

Regulatory information

United States: medicine status
FDA approval statusDuphaston (dydrogesterone) is not an FDA-approved drug product in the United States.
Prescription statusNo U.S. prescription classification applies because this product is not FDA-approved for marketing in the United States.
Safety reportingSuspected adverse events may be reported to the FDA through the MedWatch safety reporting program.

More information