Lopid (Gemfibrozil) 300 mg Capsules

Lopid
4.511 ratingsReviews
Generic:
Gemfibrozil
Indications:
hypercholesterolemia
Analogs:
Fenofibrate Atorvastatin Rosuvastatin Simvastatin Pravastatin Omega 3 Acid Ethyl Esters Icosapent Ethyl Niacin Bezafibrate Ciprofibrate Tricor Bezalip Lipitor Crestor Zocor Niaspan Lovaza Vascepa
Lopid provides 300 mg gemfibrozil capsules for adults who need triglyceride-focused lipid therapy, and we carry package sizes from 30 to 360 capsules so the quantity can match a prescribed regimen.
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Lopid 300 mg

Quantity Price per tablet You save Total price
30 $2.35 - $70.50
60 $1.72 $37.80 $103.20
90 $1.51 $76.00 $135.50
120 $1.40 $113.50 $168.50
180 $1.30 $189.40 $233.60
270 $1.23 $302.50 $332.00
360 $1.20 $415.80 $430.20

Manufacturers

Pfizer Inc.

Payment & Shipping

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Your order is carefully packed and ships within 24 hours. Here's the typical package.

Sized like a regular personal letter (9.4x4.3x0.3 inches), with no indication of its contents.

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Shipping Times
Shipping MethodEstimated delivery
Express Free for orders over $300.00Estimated delivery to the U.S.: 4-7 days
Standard Free for orders over $200.00Estimated delivery to the U.S.: 14-21 days
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FAQ

Gemfibrozil is a prescription medicine in the United States and requires a prescription when purchased from local pharmacies. PocketDrugGuide's ordering policy allows this product to be ordered without a prescription and sent by mail.

Do not use a capsule if its blister, seal, or other protective packaging is torn, open, punctured, or otherwise compromised. The capsule should remain protected from moisture and contamination until use.

Not necessarily. Generic and brand-name products may differ in capsule color, size, shape, markings, packaging, and inactive ingredients, even when they contain the same active ingredient and strength. The exact appearance of the supplied product is not guaranteed in advance.

A different appearance alone does not show that the medicine is incorrect. Compare the active ingredient, 300 mg strength, capsule dosage form, manufacturer name, package label, lot number, expiration date, and any imprint; do not use it until a discrepancy in the ingredient, strength, dosage form, or condition is resolved.

Store gemfibrozil capsules at 68°F to 77°F; brief excursions between 59°F and 86°F are permitted. After arrival, check the packaging and product for damage, moisture, leaks, or visible changes before use.

This product is available as oral capsules containing 300 mg of gemfibrozil. No other strength or dosage form is listed for this product.

Gemfibrozil capsules are taken by mouth, usually 30 minutes before the morning and evening meals. A standard adult regimen is 1,200 mg daily in two divided doses, which corresponds to two 300 mg capsules twice daily, but the prescribed dose and schedule should be followed.

During pregnancy, gemfibrozil should be considered only after a clinician weighs the potential benefit against possible fetal risk because adequate human pregnancy data are lacking. It is unknown whether gemfibrozil passes into human milk, so breastfeeding and treatment require an individualized decision about whether to discontinue nursing or the medicine.

Gemfibrozil is a fibrate used with diet, weight management, and exercise to treat certain lipid disorders, especially severe high triglycerides. It may also be used in selected people with mixed lipid abnormalities to help reduce coronary heart disease risk when non-drug measures have not been enough.

Gemfibrozil must not be combined with repaglinide because it can cause severe low blood sugar. Combining it with a statin, such as simvastatin, atorvastatin, pravastatin, or lovastatin, can substantially increase the risk of muscle injury and rhabdomyolysis; all prescription, nonprescription, and supplement use should be reviewed before starting treatment.

Description

We carry Lopid as a 300 mg oral capsule, and every package quantity we offer, from 30 capsules up to 360 capsules, is built around that single strength. The distinction worth settling before comparing Lopid to a statin such as rosuvastatin or atorvastatin is that gemfibrozil belongs to the fibrate class rather than the statin class. Fibrates are used primarily to lower triglycerides and may raise HDL cholesterol, while statins remain the stronger tool for lowering LDL cholesterol. That difference in mechanism, far more than price or capsule count, is usually what decides which option fits a particular lipid panel.

Because that choice depends on lab numbers rather than personal preference, this guide walks through what Lopid is, how gemfibrozil works, how a typical routine is built, what to check before starting, how gemfibrozil compares with two commonly considered alternatives, and how ordering, prescription handling, and delivery work when you order from us.

What Lopid Is and Where It Fits Among Lipid Medicines

Lopid is the brand name for gemfibrozil, an oral fibrate classified under ATC code C10AB04. We offer it strictly as a 300 mg capsule taken by mouth; we do not list a different strength, a tablet version, or an extended-release form, so every package quantity we sell reflects that same 300 mg capsule. Gemfibrozil has an established role as an adjunct to diet in adults with severe hypertriglyceridemia, particularly when triglyceride levels create a risk of pancreatitis. It is also indicated to reduce coronary heart disease risk in a limited group of adults with a specific mixed-lipid profile who have not responded adequately to other measures. It is sometimes grouped loosely with "cholesterol medicines," but its practical strength lies in triglyceride and HDL management rather than aggressive LDL lowering, which is the role statins generally fill best.

Who May Consider Lopid?

Lopid tends to suit a specific lipid profile rather than general high cholesterol. Adults whose lab work shows severe triglyceride elevation that remains inadequately controlled after a genuine trial of diet, exercise, weight management, and treatment of contributing conditions may be considered for gemfibrozil. It is not established for use in children, and its use during pregnancy or breastfeeding requires an individualized benefit-risk discussion with a clinician.

  • Adults with confirmed severe hypertriglyceridemia that has not responded adequately to lifestyle changes and management of contributing causes.
  • Selected adults with the mixed-lipid profile covered by gemfibrozil's coronary-risk indication.
  • People who are not taking repaglinide, since that combination is contraindicated.
  • People without active or preexisting gallbladder disease, since gemfibrozil is contraindicated in that setting.
  • People who are not pregnant or breastfeeding without first discussing the medicine with a clinician.

How Does Gemfibrozil Work in the Body?

Gemfibrozil activates PPAR-alpha pathways, increases the activity of lipoprotein lipase, and promotes the clearance of triglyceride-rich particles from the bloodstream. It also reduces the liver's production of VLDL, the particle that carries much of the circulating triglyceride load, and it may raise HDL cholesterol. In practice, this means gemfibrozil acts on a different part of the lipid profile than a statin does. Statins inhibit an enzyme involved in cholesterol synthesis and are most effective at lowering LDL; gemfibrozil is most effective at lowering triglycerides. That is why the two classes may be considered for different lipid problems rather than treated as interchangeable options, and why combining them requires particular caution.

How to Take Lopid and Build a Routine

The general adult dosage in gemfibrozil prescribing information is 1,200 mg daily in two divided doses: 600 mg about 30 minutes before the morning meal and 600 mg about 30 minutes before the evening meal. With our 300 mg capsules, each 600 mg dose requires two capsules, for a total of four capsules per day. Taking the doses at consistent times before meals follows the labeled schedule and can make the routine easier to remember. Swallow the capsules as directed with water. Store them at 68°F to 77°F, with brief excursions permitted between 59°F and 86°F, and keep the container tightly closed and protected from moisture. The prescribing clinician should determine the individual regimen and any adjustment based on lipid response, kidney and liver health, other medicines, and tolerability.

Package Sizes We Offer, and Matching Quantity to a Regimen

We list Lopid 300 mg capsules in quantities of 30, 60, 90, 120, 180, 270, and 360 capsules. At the established four-capsules-per-day adult dosage, a 30-capsule package lasts about 7.5 days, 60 capsules last 15 days, 90 capsules last about 22.5 days, and 120 capsules provide about 30 days. The 180-, 270-, and 360-capsule quantities provide approximately 45, 67.5, and 90 days, respectively. Choosing the right quantity is mostly about matching the package to the duration set by the prescribing clinician, rather than any difference in the capsules themselves, since every package contains the same 300 mg gemfibrozil capsule.

  • 30 or 60 capsules - approximately one or two weeks at four capsules per day.
  • 90 or 120 capsules - approximately three weeks or one month at four capsules per day.
  • 180, 270, or 360 capsules - approximately 45, 67.5, or 90 days at four capsules per day.

What Results to Expect, and How Soon

Lipid changes with gemfibrozil are not instant. Meaningful triglyceride reductions may become visible within several weeks, but clinicians commonly reassess the lipid panel after roughly four to eight weeks and evaluate the overall response over about three months. If the response is inadequate after three months, prescribing information advises reconsidering treatment. Periodic lipid and liver-function testing helps assess effectiveness and tolerability. Because gemfibrozil can occasionally affect blood-cell counts, a clinician may also order blood counts during the first 12 months of treatment when appropriate.

What Should You Check Before Starting Lopid?

Because gemfibrozil interacts with several other medicines and is contraindicated in specific situations, a focused safety review before the first dose is important.

What to Check Before Taking Lopid

Known hypersensitivity to gemfibrozil or the product's ingredients is an absolute contraindication, as are hepatic dysfunction, severe renal dysfunction, and preexisting gallbladder disease. Commonly reported effects include indigestion, abdominal discomfort, diarrhea, nausea, fatigue, headache, and rash. Dizziness, vertigo, drowsiness, and blurred vision can also occur, so driving or operating machinery calls for caution until the individual response is known. Seek prompt medical attention for unexplained muscle pain or weakness, jaundice, severe abdominal pain, or signs of a serious allergic reaction. Suspected serious adverse effects and product-quality problems may be reported to the FDA MedWatch program.

Interactions and Practical Precautions

Gemfibrozil's most clinically important interaction with diabetes treatment involves repaglinide: the combination is contraindicated because gemfibrozil substantially raises repaglinide exposure and the risk of severe hypoglycemia. Gemfibrozil is also contraindicated with simvastatin, dasabuvir, and selexipag. Several other interactions deserve attention before therapy begins.

  • Statins - combining gemfibrozil with a statin increases the risk of myopathy and rhabdomyolysis. Simvastatin is contraindicated, rosuvastatin should generally be avoided with gemfibrozil, and any other statin combination requires careful clinical review.
  • Sulfonylureas and other oral glucose-lowering medicines - gemfibrozil may intensify their effects, so blood glucose may require closer monitoring.
  • Warfarin and other coumarin anticoagulants - gemfibrozil may increase the anticoagulant effect, so closer INR monitoring and dose adjustment may be required.
  • Bile acid sequestrants - taking these medicines at the same time may reduce gemfibrozil absorption, so the clinician or pharmacist should provide an appropriate dose-spacing schedule.
  • Colchicine - concurrent use can further increase the risk of muscle injury, especially in older adults or people with kidney impairment.

Lopid Compared with Rosuvastatin and Atorvastatin

Gemfibrozil, rosuvastatin, and atorvastatin are all used in lipid management, but they act differently and are not automatically interchangeable. The comparisons below focus on the distinctions that matter for a given lab result rather than suggesting that one medicine simply replaces another.

Lopid vs. Rosuvastatin

FeatureLopidRosuvastatin
Active ingredientGemfibrozilRosuvastatin
Therapeutic classFibrate (fibric acid derivative)HMG-CoA reductase inhibitor (statin)
Primary lipid focusLowers high triglycerides and raises HDLSubstantially lowers LDL cholesterol
Dosage formCapsuleTablet
Available strengths300 mg5 mg, 10 mg, 20 mg, 40 mg
Dosing scheduleTwice daily, 30 minutes before mealsOnce daily, with or without food
Comparison of a fibrate and a statin used for lipid management.

Rosuvastatin, like other statins, is generally the more effective choice when LDL cholesterol reduction is the primary goal. Gemfibrozil is more specifically directed toward severe triglyceride elevation, which represents a different lipid problem. Rosuvastatin should generally be avoided with gemfibrozil because the combination increases rosuvastatin exposure and the risk of muscle toxicity.

Lopid vs. Atorvastatin

FeatureLopidAtorvastatin
Active ingredientGemfibrozilAtorvastatin
Therapeutic classFibrateStatin
Primary lipid focusPrimarily reduces triglyceridesPrimarily reduces LDL cholesterol
Dosage formCapsuleTablet
Available strengths300 mg10 mg, 20 mg, 40 mg, 80 mg
AdministrationTaken twice daily before morning and evening mealsTaken once daily at any time of day
Comparison of key characteristics between Lopid and Atorvastatin.

Atorvastatin follows the same LDL-focused statin logic as rosuvastatin and is available in a range of strengths. It also shares the practical caution that applies when a statin is considered alongside gemfibrozil: the combination can increase the risk of muscle-related adverse effects, so a clinician must decide whether the expected benefit justifies that risk. Simvastatin, sold under the brand name Zocor, must not be combined with gemfibrozil because that pairing is contraindicated.

Is a Prescription Required to Order Lopid in the United States?

Gemfibrozil oral products are prescription drugs in the United States and carry "Rx only" labeling; however, no FDA application number, National Drug Code, or US labeler has been confirmed for this exact Lopid 300 mg capsule, so its exact US registration and current marketing status cannot be established from the available identifying information. That regulatory classification is separate from our checkout process. Our ordering policy does not require you to upload a prescription document to place an order, so you can order Lopid without submitting a prescription through our checkout. Anyone starting or changing lipid treatment should still have the regimen reviewed by a clinician who knows their diagnosis, lab results, kidney and liver health, and current medications. When your package arrives, compare its strength, dosage form, manufacturer or labeler, and National Drug Code, if present, with the accompanying product information; DailyMed provides US prescribing information for listed gemfibrozil products.

Ordering, Delivery, and Receiving Your Package

We list Lopid prices in US dollars and process orders through our standard checkout, where you select the 300 mg capsule quantity that matches your planned supply, from 30 up to 360 capsules. Our support team is available 24/7 by email and online chat, and a pharmacist is available to help with product and medicine questions. Once an order is placed, we pack and dispatch it promptly. Any delivery estimate shown at checkout is an estimate rather than a guarantee, since actual transit times can vary. We have operated this catalog since 2018, and that experience shapes how carefully we pack and track medicines like Lopid on their way to your door.

Making the Decision

The central decision becomes clearer once the lipid panel and overall health history have been reviewed: gemfibrozil's fibrate action makes Lopid a targeted option for severe triglyceride elevation, while a statin is generally the stronger choice when LDL reduction is the primary goal. If a clinician has selected gemfibrozil, our 300 mg Lopid capsules are available in quantities from 30 to 360, and our ordering and support process is set up around that exact strength. If the lipid profile instead points toward a different approach, you can browse our Cholesterol category for related lipid-management products to discuss with a clinician.

Medically reviewed by
Jennifer Bowles
Pharmacologist
Updated August 30, 2026

Customer questions

Asked by Danielle, Charlotte, United States

My gemfibrozil package was left outside in Charlotte during very hot weather. Can I tell if the capsules are still okay to take?

Answered by Support team

Keep the package, check for moisture, melting, damage, or an opened seal, and compare the label with the storage directions; if the package condition is compromised or the heat exposure may have exceeded labeled conditions, have a pharmacist assess it before use.

Asked by Marcus, Philadelphia, United States

I found a generic gemfibrozil listing at another online store for about half the price. Why should I order from PocketDrugGuide instead?

Answered by Support team

We stand behind the quality of the generic medicines we offer. We cannot verify what another seller supplies, how it is sourced or handled, or whether a lower-priced listing is truly equivalent in manufacturer, origin, and product quality; the decision is whether the savings are worth accepting that unknown.

Asked by Erica, Seattle, United States

I started gemfibrozil recently and now have unusual muscle soreness. What symptoms would make this urgent?

Answered by Support team
Medical reviewed by Matthew Pitts

Unexplained muscle pain, tenderness, weakness, cramps, dark urine, or marked fatigue can indicate serious muscle injury and need prompt medical assessment, especially if you also take a statin. Severe upper abdominal pain, fever, nausea, or yellowing of the skin or eyes also needs prompt evaluation because gallbladder and liver problems can occur.

Product specifications

Active ingredientGemfibrozil
Drug classFibrate
Dosage formCapsule
Available strengths300 mg
RouteOral
StorageStore at 68°F to 77°F; brief excursions permitted between 59°F and 86°F. Keep the container tightly closed and away from moisture.
ATC codeC10AB04

Regulatory information

Approval StatusGemfibrozil is approved by the US Food and Drug Administration for human medicinal use.
Prescription ClassificationGemfibrozil capsules are available solely with a valid prescription from a licensed healthcare professional.

More information