Tofranil (Imipramine) Tablets: Prices, Strengths, and Package Options

We carry Tofranil, the brand-name imipramine tablet, and offer a genuine set of choices rather than a single fixed listing: three strengths and six package sizes for each strength, with quantities suitable for different planned supplies and reorder preferences. Before you decide what to add to your cart, it helps to see those options side by side, because the right combination of strength and quantity depends on what your prescriber has recommended and how long you expect to stay on treatment.

Tofranil (Imipramine) Tablets: Your Options at a Glance

Imipramine hydrochloride is the active ingredient in every Tofranil tablet we offer, supplied as oral tablets in 25 mg, 50 mg, and 75 mg strengths. For each strength, we offer the same six package sizes, so the decision is less about which strength has more choices and more about matching the tablet strength your prescriber selected with a package size that fits your situation.

• Strength: 25 mg, 50 mg, or 75 mg tablets, matched to the dose your prescriber has set.
• Quantity: package sizes of 60, 90, 120, 180, 270, or 360 tablets for every strength.
• Brand context: Tofranil is a brand-name imipramine tablet, distinct from unbranded generic imipramine.
• Unit value: comparing the displayed price per tablet can help you assess package value, especially for treatment you expect to continue for months.

Comparing Package Sizes and Unit Value

Unit value is a useful way to compare packages, but it is only one part of the decision. A lower price per tablet is worth less if it leads you to buy far more medication than you will use before your prescriber reassesses your treatment, or more than you can store properly before the tablets reach the end of their shelf life. We show the exact current prices, package sizes, and per-tablet value for the 50 mg strength in the comparison below. Check the selected strength carefully rather than assuming that the figures shown for 50 mg also apply to the 25 mg or 75 mg options.

When you look at the table, weigh the package size against how long your current prescription is written for, how often you would rather reorder, and whether you would prefer fewer, larger deliveries or more frequent smaller ones.

• The length of treatment your prescriber has planned, since imipramine is typically used for weeks or months rather than a single short course.
• How the tablets will be stored at home and how much stock you are comfortable keeping on hand at once.
• How close you are to any change in your prescribed dose, since a large quantity of one strength is less useful if your dose is adjusted soon.
• How often you want to place a new order versus how much you want to pay per tablet on any single order.

How Do You Choose the Right Strength and Quantity?

Strength selection for imipramine is a clinical decision made with your prescriber, who typically starts treatment at a lower dose and titrates upward based on response and tolerability. Having 25 mg, 50 mg, and 75 mg tablets available lets a prescriber build a wide range of daily doses, and it also allows a dose to be adjusted, tapered, or divided across strengths without switching to an entirely different product.

Once your strength and prescribed number of tablets per day are set, calculate how long each package would last. A 60-tablet package is the smallest option we offer, while 270 or 360 tablets may reduce reorder frequency for an established regimen when that quantity matches your planned supply and can be used before expiry.

Tofranil Brand Tablets and How They Compare to Generic Imipramine

Tofranil is a branded imipramine tablet. Generic imipramine hydrochloride tablets of the same strength provide the same active ingredient in the same dosage form and route. Some people choose the brand because they have used it before and prefer consistency in appearance or supplier, while others move to generic imipramine mainly for cost once they know the medication suits them. Because imipramine belongs to the older tricyclic antidepressant class, some patients and prescribers instead look toward newer antidepressants with different side-effect and interaction profiles, such as Paxil (paroxetine); that kind of switch is a prescribing decision based on tolerability and history rather than a simple price comparison.

What Tofranil Is Used For

Imipramine's primary approved use is the treatment of depression in adults, where it works as part of a broader treatment plan that may include counseling or other support. It also has a specific, well-established pediatric use for nocturnal enuresis (bedwetting) in children aged six and older, at a defined maximum daily dose based on body weight. Older clinical literature also describes imipramine's use in panic disorder, though current first-line options for that condition are usually newer antidepressants.

• Major depressive disorder in adults, as an oral tricyclic antidepressant.
• Nocturnal enuresis in children aged 6 and older, dosed according to body weight.
• Historical and sometimes continued off-label use for panic disorder, guided by a prescriber's assessment.

How Does Imipramine Work, and How Should You Take It?

Imipramine works mainly by inhibiting the reuptake of norepinephrine and serotonin in the brain, which is thought to underlie its antidepressant effect, while its additional anticholinergic and antihistaminic activity accounts for much of its sedating quality and for several of its side effects. Tablets can be taken with or without food, and taking a dose with food may ease stomach upset for people who are sensitive to it. Because imipramine can be sedating, many people take the bulk of their daily dose in the evening once their prescriber has settled on a stable regimen. Antidepressant benefit typically builds gradually, often over two to four weeks, so not noticing improvement early in treatment does not necessarily mean the medication will not work. Imipramine should not be stopped abruptly after regular use; your prescriber will usually guide a gradual dose reduction instead.

Safety Considerations and Drug Interactions to Keep in Mind

Imipramine carries a boxed warning about increased risk of suicidal thoughts and behavior, particularly in children, adolescents, and young adults, which is why close monitoring during early treatment and after dose changes matters. Its anticholinergic effects can cause dry mouth, constipation, blurred vision, and urinary retention, and it can affect heart rhythm and blood pressure, so people with existing heart conditions are usually evaluated carefully before starting it. Imipramine can also affect blood glucose levels in either direction, which is relevant for anyone managing diabetes, and it may cause drowsiness that affects driving or operating machinery.

• Monoamine oxidase inhibitors (MAOIs), which are contraindicated with imipramine due to the risk of a serious interaction.
• Other serotonergic medications, which can raise the risk of serotonin-related side effects when combined with imipramine.
• Other anticholinergic drugs, which can add to dry mouth, constipation, or urinary retention.
• Certain antidepressants and other CYP2D6 inhibitors, which can raise imipramine blood levels.
• Alcohol, which can intensify sedation and impair coordination.

Imipramine Access and Prescription Requirements in the United States

Imipramine is classified as a prescription medicine in the United States, and that classification describes the medicine's legal status rather than our own checkout requirements. Our ordering process does not require you to submit a prescription before we accept your order for Tofranil, and our pharmacist-supported team is available by email or online chat, 24/7, if you have questions about strength, dosing information, or your order before you decide. Because Medicare Part D coverage, formulary placement, and cost-sharing for imipramine vary by plan, it is worth checking your own plan's terms alongside our listed package prices before you order.

How Ordering, Packing, and Delivery Work With Us

We have supported customers ordering medications like Tofranil since 2018, and our process is built to make selecting the right strength and package size straightforward from browsing through checkout. Once your order is placed, our team packs it and prepares it for dispatch, and our delivery process is designed to get your package to you reliably, with support available if you need to check on an order's status.

• Select the strength and package quantity that match your prescription and planned supply.
• Complete checkout, where the exact price and package are confirmed before you pay.
• Our team packs and dispatches your order.
• You receive delivery, with our support team available by email or chat, 24/7, if you have any questions along the way.

Choosing the Package That Matches Your Treatment Plan

The lowest price per tablet is worth having, but only alongside the right strength and a quantity that fits how long you expect to stay on this dose. Store your tablets at 68°F to 77°F, with brief excursions permitted between 59°F and 86°F, in a tightly closed, light-resistant container away from light and moisture, so a larger package stays usable for the length of time you plan to take it. Match the strength on the label to what your prescriber has set, choose a quantity that lines up with your expected treatment length and reorder preference, and let our current package pricing help you settle the practical side of that decision once the clinical side is already in place.