| Quantity | Price per tablet | You save | Total price | |
|---|---|---|---|---|
| 20 | £4.26 | - | £85.19 | |
| 30 | £4.12 | £4.07 | £123.71 | |
| 60 | £3.79 | £28.15 | £227.43 | |
| 90 | £3.41 | £76.67 | £306.69 | |
| 120 | £3.16 | £131.86 | £379.29 | |
| 180 | £2.91 | £243.72 | £523.00 | |
| 270 | £2.66 | £433.00 | £717.09 | |
| 360 | £2.53 | £623.75 | £909.70 |
| Quantity | Price per tablet | You save | Total price | |
|---|---|---|---|---|
| 10 | £6.74 | - | £67.41 | |
| 20 | £5.30 | £28.89 | £105.93 | |
| 30 | £4.79 | £58.52 | £143.72 | |
| 60 | £4.42 | £139.27 | £265.21 | |
| 90 | £4.21 | £227.43 | £379.29 | |
| 120 | £4.07 | £320.77 | £488.19 | |
| 180 | £3.77 | £534.86 | £678.57 | |
| 270 | £3.48 | £880.07 | £940.08 | |
| 360 | £3.19 | £1,277.14 | £1,149.72 |
| Quantity | Price per tablet | You save | Total price | |
|---|---|---|---|---|
| 10 | £27.04 | - | £270.39 | |
| 20 | £22.59 | £88.90 | £451.89 |
Your order is carefully packed and ships within 24 hours. Here's the typical package.
Sized like a regular personal letter (24x11x0.7 cm), with no indication of its contents.
| Delivery Method | Estimated delivery |
|---|---|
| Express Free for orders over £222.24 | Estimated delivery to the UK: 4-7 days |
| Standard Free for orders over £148.16 | Estimated delivery to the UK: 14-21 days |
| Country | Brand Names |
|---|---|
| United Kingdom | Adoport Advagraf |
| Australia | Advagraf |
| Canada | Advagraf |
| United States | Astagraf XL |
Several drugs are particularly well-known in the pharmaceutical industry for their exceptional ability to treat various medical ailments. Prograf is among such medications. Prograf is frequently administered to patients undergoing transplantation and to those suffering from particular autoimmune illnesses. It is essential in suppressing the immune system to avoid organ rejection or lessen autoimmune disease symptoms.
Prograf, sometimes referred to as tacrolimus in its generic form, is an immunosuppressive drug. It limits the body's immunological response by blocking the functioning of specific immune system cells. This immunosuppressive effect is essential in keeping the recipient's immune system from rejecting transplanted organs such as the liver, heart, kidneys, or lungs.
Prograf's capacity to connect to a protein known as FK-binding protein-12 (FKBP-12) is part of its mode of action. Then, this Prograf-FKBP-12 combination inhibits the calcineurin enzyme. The immune response is mediated by T-lymphocytes, a subset of white blood cells activated by calcineurin. Prograf reduces the activation of T-lymphocytes and their subsequent proliferation by blocking calcineurin, which in turn attenuates the immunological response.
Uses of Prograf| Indication | Initial Oral Dose | Maintenance Oral Dose Range | Monitoring |
|---|---|---|---|
| Kidney Transplantation | 0.10 - 0.20 mg/kg/day in 2 divided doses | 0.05 - 0.15 mg/kg/day in 2 divided doses, adjusted based on clinical response and tacrolimus trough levels | Tacrolimus trough levels (e.g., 5-15 ng/mL) should be monitored regularly, typically 2-3 times per week initially, then less frequently |
| Liver Transplantation | 0.10 - 0.20 mg/kg/day in 2 divided doses | 0.05 - 0.15 mg/kg/day in 2 divided doses, adjusted based on clinical response and tacrolimus trough levels | Tacrolimus trough levels (e.g., 5-20 ng/mL) should be monitored regularly, typically 2-3 times per week initially, then less frequently |
| Heart Transplantation | 0.075 - 0.15 mg/kg/day in 2 divided doses | 0.05 - 0.10 mg/kg/day in 2 divided doses, adjusted based on clinical response and tacrolimus trough levels | Tacrolimus trough levels (e.g., 5-15 ng/mL) should be monitored regularly, typically 2-3 times per week initially, then less frequently |
| Lung Transplantation | 0.075 - 0.15 mg/kg/day in 2 divided doses | 0.05 - 0.10 mg/kg/day in 2 divided doses, adjusted based on clinical response and tacrolimus trough levels | Tacrolimus trough levels (e.g., 5-15 ng/mL) should be monitored regularly, typically 2-3 times per week initially, then less frequently |
Prograf has drawbacks even though it works wonders in controlling autoimmune disorders and preventing organ rejection. Among the most common adverse effects of using Prograf are:
Prograf, or tacrolimus, is a potent immunosuppressive drug frequently used to treat autoimmune diseases and facilitate organ donation. Healthcare practitioners can maximize the use of this medication while lowering patient risks by being aware of its mechanism of action, indications, and possible side effects. In spite of its adverse effects, Prograf is still a vital weapon in the fight against autoimmune illnesses and organ rejection, providing countless people all over the world with hope for better results and a higher standard of living.
I'm in Belfast. Can I check whether tacrolimus can be delivered to my address before I pay?
Yes. Please enter your Belfast delivery address at checkout and review the delivery options shown there. Availability for a particular address is confirmed by the options presented during checkout.
Before ordering, how can I tell how many tacrolimus capsules are in the pack?
Choose the pack quantity on the product page before adding it to your basket. Available pack sizes are 10, 20, 30, 60, 90, 120, 180, 270 and 360 capsules.
My GP has suggested clarithromycin for a chest infection, but I take tacrolimus after a kidney transplant. Can I take them together?
Clarithromycin can substantially raise tacrolimus blood levels and increase the risk of toxicity, including kidney and neurological effects. The prescriber and transplant team need to know before it is started so that an alternative or close tacrolimus-level monitoring can be arranged.
| Active ingredient | Tacrolimus |
|---|---|
| Drug class | Calcineurin inhibitor immunosuppressant |
| Dosage form | Capsule |
| Available strengths | 0.5 mg, 1 mg, 5 mg |
| Route | Oral |
| Storage | Store the capsules between 5°C and 25°C in the original container, protected from moisture. |
| ATC code | L04AD02 |
This product has 41 ratings, but only 3 written reviews so far. Share your experience and help other customers.
Very satisfied overall.
The order for tacrolimus looked like an ordinary delivery and revealed nothing about its contents.
Excellent quality on arrival.
