| Quantity | Price per tablet | You save | Total price | |
|---|---|---|---|---|
| 20 | C$4.07 | - | C$81.48 | |
| 30 | C$3.87 | C$6.16 | C$116.06 | |
| 60 | C$3.59 | C$29.12 | C$215.32 | |
| 90 | C$3.23 | C$76.16 | C$290.50 | |
| 120 | C$2.98 | C$131.32 | C$357.56 | |
| 180 | C$2.74 | C$240.24 | C$493.08 | |
| 270 | C$2.51 | C$421.26 | C$678.72 | |
| 360 | C$2.39 | C$607.74 | C$858.90 |
| Quantity | Price per tablet | You save | Total price | |
|---|---|---|---|---|
| 10 | C$6.40 | - | C$63.98 | |
| 20 | C$4.98 | C$28.28 | C$99.68 | |
| 30 | C$4.48 | C$57.54 | C$134.40 | |
| 60 | C$4.16 | C$134.12 | C$249.76 | |
| 90 | C$3.99 | C$216.44 | C$359.38 | |
| 120 | C$3.85 | C$305.62 | C$462.14 | |
| 180 | C$3.57 | C$509.32 | C$642.32 | |
| 270 | C$3.29 | C$838.04 | C$889.42 | |
| 360 | C$3.02 | C$1,215.90 | C$1,087.38 |
| Quantity | Price per tablet | You save | Total price | |
|---|---|---|---|---|
| 10 | C$25.54 | - | C$255.36 | |
| 20 | C$21.34 | C$84.00 | C$426.72 |
Your order is carefully packed and ships within 24 hours. Here's the typical package.
Sized like a regular personal letter (24x11x0.7 cm), with no indication of its contents.
| Shipping Method | Estimated delivery |
|---|---|
| Express Free for orders over C$420.00 | Estimated delivery to Canada: 4-7 days |
| Standard Free for orders over C$280.00 | Estimated delivery to Canada: 14-21 days |
| Country | Brand Names |
|---|---|
| Canada | Advagraf |
| United States | Astagraf XL |
| United Kingdom | Adoport Advagraf |
| France | Advagraf |
| Australia | Advagraf |
| Germany | Advagraf |
| Italy | Advagraf |
 Belgium | Prograft Protopic |
Several drugs are particularly well-known in the pharmaceutical industry for their exceptional ability to treat various medical ailments. Prograf is among such medications. Prograf is frequently administered to patients undergoing transplantation and to those suffering from particular autoimmune illnesses. It is essential in suppressing the immune system to avoid organ rejection or lessen autoimmune disease symptoms.
Prograf, sometimes referred to as tacrolimus in its generic form, is an immunosuppressive drug. It limits the body's immunological response by blocking the functioning of specific immune system cells. This immunosuppressive effect is essential in keeping the recipient's immune system from rejecting transplanted organs such as the liver, heart, kidneys, or lungs.
Prograf's capacity to connect to a protein known as FK-binding protein-12 (FKBP-12) is part of its mode of action. Then, this Prograf-FKBP-12 combination inhibits the calcineurin enzyme. The immune response is mediated by T-lymphocytes, a subset of white blood cells activated by calcineurin. Prograf reduces the activation of T-lymphocytes and their subsequent proliferation by blocking calcineurin, which in turn attenuates the immunological response.
Uses of Prograf| Indication | Initial Oral Dose | Maintenance Oral Dose Range | Monitoring |
|---|---|---|---|
| Kidney Transplantation | 0.10 - 0.20 mg/kg/day in 2 divided doses | 0.05 - 0.15 mg/kg/day in 2 divided doses, adjusted based on clinical response and tacrolimus trough levels | Tacrolimus trough levels (e.g., 5-15 ng/mL) should be monitored regularly, typically 2-3 times per week initially, then less frequently |
| Liver Transplantation | 0.10 - 0.20 mg/kg/day in 2 divided doses | 0.05 - 0.15 mg/kg/day in 2 divided doses, adjusted based on clinical response and tacrolimus trough levels | Tacrolimus trough levels (e.g., 5-20 ng/mL) should be monitored regularly, typically 2-3 times per week initially, then less frequently |
| Heart Transplantation | 0.075 - 0.15 mg/kg/day in 2 divided doses | 0.05 - 0.10 mg/kg/day in 2 divided doses, adjusted based on clinical response and tacrolimus trough levels | Tacrolimus trough levels (e.g., 5-15 ng/mL) should be monitored regularly, typically 2-3 times per week initially, then less frequently |
| Lung Transplantation | 0.075 - 0.15 mg/kg/day in 2 divided doses | 0.05 - 0.10 mg/kg/day in 2 divided doses, adjusted based on clinical response and tacrolimus trough levels | Tacrolimus trough levels (e.g., 5-15 ng/mL) should be monitored regularly, typically 2-3 times per week initially, then less frequently |
Prograf has drawbacks even though it works wonders in controlling autoimmune disorders and preventing organ rejection. Among the most common adverse effects of using Prograf are:
Prograf, or tacrolimus, is a potent immunosuppressive drug frequently used to treat autoimmune diseases and facilitate organ donation. Healthcare practitioners can maximize the use of this medication while lowering patient risks by being aware of its mechanism of action, indications, and possible side effects. In spite of its adverse effects, Prograf is still a vital weapon in the fight against autoimmune illnesses and organ rejection, providing countless people all over the world with hope for better results and a higher standard of living.
My tacrolimus package arrived in Quebec City during a very cold spell. What should I check before I use the capsules?
Check that the outer package and original container are intact, dry, and properly labelled, and that the capsules have no visible damage or unusual appearance. Store them between 5°C and 25°C in the original container, protected from moisture.
I have used Prograf before. Will the package I receive show that brand name, or could it have a generic or manufacturer name instead?
We cannot guarantee the exact trade name shown on the package. It may show a generic or manufacturer name instead; confirm that the label states tacrolimus, the prescribed strength, and capsules before taking it.
I have just started tacrolimus after my transplant. Which side effects should I report to my transplant clinic urgently?
Contact the transplant clinic promptly for fever, chills, persistent cough, painful urination, severe headache, confusion, seizures, marked tremor, vision changes, reduced urine, swelling, or unusual weakness. Tacrolimus can increase infection risk and may affect the kidneys, nervous system, blood pressure, potassium, and blood sugar, so these symptoms need timely assessment.
| Active ingredient | Tacrolimus |
|---|---|
| Drug class | Calcineurin inhibitor immunosuppressant |
| Dosage form | Capsule |
| Available strengths | 0.5 mg, 1 mg, 5 mg |
| Route | Oral |
| Storage | Store the capsules between 5°C and 25°C in the original container, protected from moisture. |
| ATC code | L04AD02 |
This product has 37 ratings, but only 5 written reviews so far. Share your experience and help other customers.
Prograf order was packed properly.
The purchase was straightforward; the price was the only drawback.
Order received, no problem at all.
I'd order again.
Everything went smoothly.
