Naltrexone 50 mg Tablets

If you are weighing naltrexone against other options for alcohol or opioid dependence, the detail that matters most is how you take it: a once-daily 50 mg tablet you control yourself, rather than a monthly injection administered by a clinician. That single difference shapes cost per dose, how quickly you can start or stop, and how much the outcome depends on remembering to take a pill every day. We offer Naltrexone 50 mg oral tablets in packages of 30, 60, and 90, so you can match the listing to a planned course rather than buying in a format that does not fit your routine.

Naltrexone 50 mg Tablets: What Makes This Product Different

Naltrexone is an opioid antagonist, meaning it occupies opioid receptors without activating them. The tablets we sell are oral tablets containing 50 mg of naltrexone. They should not be confused with extended-release injectable formulations that use the same active ingredient but a completely different route and dosing schedule. Oral naltrexone is established for two related but distinct uses: supporting abstinence in alcohol dependence by blunting the rewarding effect of drinking, and maintaining an opioid-free state after detoxification by blocking the euphoric and sedating effects of opioids if they are used. Because the tablet form depends on the person taking it consistently, its practical value is closely tied to motivation and routine, which is worth weighing honestly before choosing it over an alternative.

Who May Consider Naltrexone Tablets?

Naltrexone tablets are generally considered by adults who have stopped drinking or who have completed opioid detoxification and want help avoiding relapse. It is not a detox medication and will not treat withdrawal on its own. People exploring broader information about treatment for alcohol dependence can visit our Alcoholism page while considering which approach may fit their situation.

• Adults who have stopped drinking and want to reduce the rewarding effect of a future drink
• Adults who have completed opioid withdrawal and need ongoing blockade to support an opioid-free state
• People who prefer a daily oral tablet they control, rather than a scheduled injection
• People without significant liver impairment, since naltrexone is processed by the liver
• People who are not currently using opioids, including prescription pain medication

How Does Naltrexone Work in the Brain?

Naltrexone binds competitively to mu-opioid receptors in the central nervous system. When opioid receptors are blocked, opioids cannot produce their usual rewarding or sedating effect. In alcohol dependence, modulation of endogenous opioid reward pathways can reduce the reinforcing effects associated with drinking. The diagram below sets out this sequence step by step, which is useful context for understanding why consistent daily dosing matters more with naltrexone than with medications that work through a different mechanism.

In practice, this receptor-level action means naltrexone does not create a pleasurable effect itself and does not cause physical dependence. It reduces opioid reward directly and can reduce the reinforcing effects of alcohol, which is why it works best as part of a broader treatment plan that includes counselling or structured support rather than as a stand-alone fix.

Building a Daily Naltrexone Routine

A standard adult regimen is one 50 mg tablet taken once daily, usually at the same time each day to build a routine that is easy to sustain. Naltrexone can be taken with or without food, though taking it with a meal may reduce the nausea some people notice when they start. Before beginning oral naltrexone, a person must be opioid-free because taking it while opioids are still active can trigger sudden, severe withdrawal. The usual minimum interval is 7 to 10 days after the last use of a short-acting opioid, but a longer interval may be necessary after methadone or buprenorphine; a clinician should determine when it is safe to start.

• Take the tablet at the same time every day to reduce missed doses
• Taking it with food can ease early nausea without reducing its effect
• Do not start naltrexone while opioids, including codeine-containing products, are still in your system
• Do not double a dose after a missed tablet; follow the instructions provided by your prescriber or pharmacist
• Store tablets at 20°C to 25°C, with excursions permitted between 15°C and 30°C; keep the container tightly closed and protect it from light

The Package Sizes We Offer

We currently list Naltrexone 50 mg tablets in three package sizes, which lets customers choose between a short trial supply and a longer planned course without paying for a format that does not suit their timeline.

• 30 tablets, suited to a one-month course or an initial trial
• 60 tablets, suited to a two-month course with fewer reorders
• 90 tablets, suited to customers continuing an established daily routine

All three package sizes contain the same 50 mg oral tablet; the difference is purely quantity, which keeps dosing decisions consistent regardless of which size you choose.

When Can You Expect Results?

Naltrexone begins blocking opioid receptors within one to two hours of a dose, but its clinical value shows up gradually rather than immediately. For alcohol dependence, many people notice a reduction in the urge to keep drinking once they have a drink, and a general softening of cravings, over the first several weeks of consistent daily use. For relapse prevention after opioid dependence, the practical benefit is the removal of much of the expected opioid effect if opioids are used, which supports continued abstinence rather than producing a noticeable day-to-day sensation. Naltrexone does not need to build up in the body the way some psychiatric medications do, but its real-world benefit depends heavily on regular dosing because gaps can reduce continuous receptor blockade.

Important Safety Priorities

Naltrexone is generally well tolerated, but a few safety points deserve particular attention before starting treatment.

• Liver function should be assessed before starting and monitored as clinically appropriate, since naltrexone can raise liver enzymes, particularly at higher-than-labelled doses
• Naltrexone must not be started during current opioid use, opioid dependence, or acute opioid withdrawal because it can precipitate severe withdrawal
• Naltrexone is contraindicated in acute hepatitis or liver failure and should be used cautiously in people with other liver disease
• Anyone with known hypersensitivity to naltrexone or a tablet ingredient should not take it
• Do not attempt to overcome the opioid blockade by taking larger opioid doses, as this can cause serious or fatal overdose
• After naltrexone is stopped, reduced opioid tolerance can make previously tolerated opioid amounts dangerous and increase overdose risk
• If naltrexone needs to be stopped for planned surgery or significant pain management, this should be arranged well in advance
• Common side effects include nausea, headache, dizziness, fatigue, and trouble sleeping, most of which ease within the first couple of weeks
• Driving or operating machinery should be approached cautiously until you know how naltrexone affects you, since dizziness and drowsiness can occur

These safety priorities are the same for the 30-, 60-, and 90-tablet package sizes.

Interactions and Practical Precautions

The most clinically significant interaction involves opioid-containing medications. Because naltrexone blocks opioid receptors, it will also block or reduce the pain-relieving effect of opioid analgesics and the effect of opioid-containing cough suppressants, which matters for anyone who may need strong pain control for an injury, dental work, or surgery.

• Opioid pain relievers and opioid-containing cough or cold products may not work as expected while naltrexone is active
• Tell any treating clinician, dentist, or surgeon that you are taking naltrexone before a procedure that may require opioid pain control
• Combining naltrexone with other medications that may affect the liver warrants extra caution and appropriate monitoring
• Alcohol itself is not blocked by naltrexone in the way opioids are; naltrexone may reduce the reward associated with drinking but does not prevent intoxication, so normal alcohol-related precautions still apply

Naltrexone Compared with Other Alcohol-Dependence Treatments

Naltrexone is one of several established medical approaches to alcohol dependence, and the right choice depends on mechanism, dosing pattern, organ function, and personal tolerance rather than on any single medication being universally superior. The comparisons below set out the practical distinctions most relevant to a purchase decision.

Naltrexone and Acamprosate

Acamprosate works through a different pathway, modulating glutamate and GABA activity rather than blocking opioid receptors, and it is typically started only after a person has already achieved abstinence, with dosing spread across the day rather than once daily. People with liver concerns may sometimes find acamprosate a more suitable option because it is not significantly metabolized by the liver, whereas kidney impairment can require dose adjustment or rule out its use. Those who want a single daily tablet that can reduce alcohol craving and also block opioid effects may prefer naltrexone when it is medically appropriate.

Naltrexone and Disulfiram

Disulfiram takes an entirely different approach: rather than reducing craving, it produces an unpleasant physical reaction if alcohol is consumed, which works as a deterrent rather than an anti-craving mechanism. We also carry Antabuse tablets, the branded form of disulfiram, for customers whose treatment plan favours an aversive strategy over a receptor-blocking one. Naltrexone does not cause the disulfiram-like reaction associated with drinking alcohol, so it may be a better fit when reducing reward and relapse risk is preferred to an aversive strategy, although treatment should still follow professional guidance on abstinence.

Oral Naltrexone Tablets and Vivitrol

The oral tablets we sell should not be confused with extended-release injectable naltrexone, which delivers the same active ingredient through a monthly intramuscular injection administered by a clinician rather than a tablet taken at home. The injectable form removes the need for daily adherence but requires a clinic visit each month and a different cost structure; the oral tablets we offer give you direct control over timing and dosing at home, which suits people who are confident in a daily routine and want to avoid monthly clinical appointments.

Is Naltrexone Available Without a Prescription in Canada?

Naltrexone is authorised for human medicinal use in Canada, and the 50 mg oral tablet is classified as a prescription medication under Canadian regulation. That regulatory classification is separate from how we process orders: our checkout does not require you to submit a prescription before we accept and prepare your order, so you can order naltrexone tablets without a prescription through our store. This ordering convenience does not change the underlying prescription status of the tablet itself, and anyone with specific health conditions, current opioid use, or liver concerns should still confirm suitability with a pharmacist or physician before starting treatment.

Ordering, Delivery, and Receiving Your Naltrexone

We have operated as an online pharmacy catalogue since 2018, and our support team is available 24/7 by email and online chat, with a pharmacist on hand to answer questions about naltrexone or any other product before or after you order. Prices are listed in Canadian dollars, and you can choose between the 30, 60, or 90-tablet packages depending on how long a course you are planning. Once an order is placed, we pack it for dispatch and provide delivery across Canada, with delivery timelines presented as estimates rather than guarantees, since transit times can vary by destination and carrier. If a package is delayed or arrives with a problem, our support channels remain open to help resolve it quickly.

Making Your Decision

Choosing naltrexone tablets over an alternative usually comes down to wanting a daily oral medication that blocks opioid receptor activity, reduces the reward associated with drinking or opioid use, and fits into a self-managed routine rather than a clinic-based injection schedule. We offer the 50 mg tablets in three package sizes so you can start with a shorter trial or commit to a longer course once you know the routine works for you, and our support and pharmacist access remain available throughout, from your first question to delivery and beyond.