Arthritis

Arthritis is an inflammatory disease of a joint. If you feel arthritis pain in the joints, especially when walking – this is the sign of arthritis. Sometimes the skin, covering the sick joint begins to blush, I some cases the rush appears.

If you have pain in only one joint, it is called monoarthritis. But, unfortunately, the disease of multiple joints is a more common form of arthritis. Arthritis develops rapidly, with sudden pain (in such case it is called acute arthritis) or gradual pain – in such case it is called chronic arthritis.

Rheumatism of joints is a chronic disease when the inflammation of the connective tissue, with a primary lesion of heart and joints takes place.

Rheumatoid arthritis is an infectious and allergic disease with a lesion of tissue of the joints. This arthritis can sometimes spread to internal organs. During rheumatoid arthritis chronic inflammation of the joints of the limbs is noticed. If one treats the affected areas of the body carelessly, it can lead to complications and the patient may have troubles walking. This is a very serious disease which mainly occurs among the people at the middle age and older.

Osteoarthritis is a common form of arthritis. The symptoms of this disease are less severe than those of rheumatoid arthritis. This type of arthritis can be treated with pharmaceutical drugs that are available in our pharmacy.

Various anti-inflammatory drugs are used to reduce inflammation and pain. The best would be the treatment that combines pharmaceuticals and medical gymnastics. It is possible to reduce pain, swelling and inflammation with the help of therapeutic massage. According to statistics, arthritis cuts life short by 10 years. Today, unfortunately, there is no drug that could cure rheumatoid arthritis.

Arthritis is an inflammation of the joints. Arthritis is characterized by pain when moving or lifting heavy objects; the joint loses mobility, swelling, changes shape, the skin over the joint is red, there is fever. Arthritis can occur rapidly, forming an acute arthritis or gradually – chronic arthritis. The factors of formation of arthritis are infection, allergy, and malnutrition joint. Arthritis can be a separate disease or a manifestation of a disease. About every hundredth person I sick with arthritis . Arthritis is the disease of the people of all ages, most often – middle-aged women and the elderly. 80% of people over 65 suffer from arthritis.

Symptoms that accompany arthritis:

  • Tightness
  • increase tissue temperature above it
  • Pain in the affected joint
  • Swelling
  • Restriction of mobility

If you do not experience too severe pains in the joints, your should use simple analgesics (paracetamol), since they prescribe as non-steroidal anti-inflammatory drugs.

Today, much attention is paid to the development of arthritis drugs, which not only can eliminate the pain but also to prevent, slow or reverse the development of pathological processes that occur in the joints during the disease of arthritis. Such drugs are called chondroprotector, i.e. drugs that protect the cartilage. They can stimulate the synthesis of the main substance of the cartilage and at the same time inhibit the production of an enzyme that destroys cartilage. Therefore, chondroprotectors enhance recovery and exacerbate the destructive processes in the cartilage. Their usage often significantly reduces the pain, increases range of motion, and restores joint function. Chondroprotectors are well tolerated and rarely cause side effects.

Pathogenesis Of Joint Damage

Although the cause of rheumatoid arthritis remains elusive, the destructive features of the disease have been extensively documented and described. The following sections review each key element of disease pathogenesis. They include the infiltration of lymphocytes and macrophages into synovial tissue, hyperplasia of synovial cells, and the enhanced expression of multiple inflammatory mediators, such as cytokines and degradative enzymes.

Immunosuppressants

Even though immunosuppressive agents such as azathioprine (Glax-oSmithKline’s Imuran, generics) and cyclosporine (Novartis’ Sandimmune/Neoral, generics) have been used for decades to treat the signs and symptoms of rheumatoid arthritis, development of novel agents in this class for rheumatoid arthritis has been sluggish because of efficacy and safety concerns that have arisen in clinical trials of agents under development. Nonetheless, companies are pursuing development of immunosuppressive therapies. Immunosuppressants function through a variety of mechanisms, but they generally target key immunologic processes and molecules.

Celecoxib

Pfizer markets this agent in all the countries under study except Japan, where Astellas Pharma (formerly Yamanouchi Pharmaceuticals, which merged with Fujisawa Pharmaceuticals on April 1, 2005, to form Astellas Pharma) is guiding it through clinical development. A new drug application (NDA) for pain and other symptoms of rheumatoid arthritis and OA was submitted in Japan in December 2002, with approval expected in 2004, but the application was still under consideration at the time of the writing of this report.

Corticosteroids

Corticosteroids have long been employed in the treatment of rheumatoid arthritis and remain a key component of symptom management. They produce potent, rapid suppression of inflammation with consequent improvements in joint pain and swelling.

Arthritis

Osteoarthritis, or OA, usually strikes weight-bearing joints such as the knees and hips, but can also affect the elbows, fingers, neck, spine, and wrists. Joints that have suffered previous injuries or infection appear to be the most vulnerable to the disease, but the simple wear and tear of aging can also aggravate the condition.