Nolvadex (Tamoxifen) OTC

Last updated on February 20, 2024

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Nolvadex may be marketed under different names in various countries. All of them contain Tamoxifen as main ingredient. Some of them are the following: Adifen, Adopan, Apo-Tamox, Bagotam, Bilem, Bioxifeno, Citofen, Crisafeno, Cryoxifeno, Defarol, Diemon, Dignotamoxi, Doctamoxifene, Ebefen, Emalook, Estrocur, Estroxyn, Farmifeno, Femoxtal, Fenobest, Festone, Genox, Ginarsan, Gynatam, Jenoxifen, Kessar, Ledertam, Lesporene, Luzamoxin, Mamofen, Mandofen, Mastofen, Neophedan, Nolgen, Nomafen, Norxifen, Nourytam, Novofen, Noxitem, Oncotam, Oncotamox, Oxeprax, Panleef, Phenolurn, Puretam, Ralsifen-X, Respol, Rolap, Sinmaren, Soltamox, Tadex, Tamaxin, Tamec, Tamexin, Tamifen, Tamizam, Tamobeta, Tamofen, Tamofene, Tamokadin, Tamona, Tamone, Tamoneprin, Tamooex, Tamopham, Tamophar, Tamoplex, Tamosin, Tamox, Tamoxan, Tamoxasta, Tamoxen, Tamoxene, Tamoxi, Tamoxifène, Tamoxigenat, Tamoximerck, Tamoxin, Tamoxis, Tamoxistad, Tamsulon, Tasuomin, Taxfeno, Taxofen, Taxus, Tecnofen, Tecnotax, Terimon, Trimetrox, Virtamox, Yacesal, Zemide, Zitazonium, Zymoplex, duratamoxifen.

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What Is Nolvadex (Tamoxifen)?

Nolvadex, or tamoxifen, is a medication commonly used in the treatment of breast cancer. It belongs to a class of drugs known as selective estrogen receptor modulators (SERMs). Tamoxifen works by blocking the effects of estrogen, a hormone that can promote the growth of certain types of breast cancer cells. It is often prescribed to individuals with hormone receptor-positive breast cancer, where estrogen receptors play a significant role in the cancer’s development.

Tamoxifen: Breast Cancer

In addition to its use in breast cancer treatment, tamoxifen may also be prescribed as a preventive measure for individuals at high risk of developing breast cancer. It’s important to note that while tamoxifen has proven benefits, it also comes with potential side effects, and its use should be discussed thoroughly with a healthcare professional.


The active ingredient in Nolvadex is tamoxifen citrate. Tamoxifen citrate is a SERM (selective estrogen receptor modulator) that works by blocking the effects of estrogen in specific tissues, particularly in the breast. This helps to inhibit the growth of estrogen-dependent breast cancer cells.

Apart from the active ingredient, the composition of pharmaceuticals may also include inactive ingredients or excipients. These can vary depending on the specific formulation and brand of the medication. In the case of Nolvadex, these inactive ingredients may include fillers, binders, and coatings that help manufacture and stabilize the drug.

It’s crucial to consult the specific product’s package insert or consult a healthcare professional for detailed information on the ingredients in a particular formulation of Nolvadex.


Nolvadex, or tamoxifen, is primarily used for the treatment of breast cancer, especially in cases where the cancer is hormone receptor-positive. Hormone receptor-positive breast cancers rely on estrogen for growth, and tamoxifen helps to block the effects of estrogen on cancer cells.

Tamoxifen is often prescribed to both pre- and postmenopausal women with hormone receptor-positive breast cancer. It can be used as part of the initial treatment or after surgery, chemotherapy, or radiation therapy to reduce the risk of cancer recurrence.

In some cases, Nolvadex may be used as a preventive measure in women at high risk of developing breast cancer. It has been shown to reduce the incidence of breast cancer in women with a high risk of the disease.

Tamoxifen may be used in the treatment of ductal carcinoma in situ, a non-invasive form of breast cancer.

In cases where breast cancer has spread to other parts of the body, tamoxifen may be used to help control the growth of cancer cells.

It’s important to note that a healthcare professional should determine the use of Nolvadex, and the benefits and risks should be thoroughly discussed with the patient. The medication is not suitable for all types of breast cancer, and individual factors such as hormonal status and overall health play a role in the decision to prescribe tamoxifen.

Dosage Sizes

The dosage of Nolvadex (tamoxifen) can vary depending on the specific medical condition being treated. It’s crucial to follow the prescribed dosage and instructions a healthcare professional provides. Dosages may be adjusted based on individual patient characteristics and response to the medication. Here are some general guidelines:

  • Breast Cancer Treatment: For adjuvant treatment of breast cancer, the typical dosage is 20 mg once daily for 5 years.
  • Breast Cancer Prevention: For the prevention of breast cancer in high-risk individuals, the usual dosage is also 20 mg once daily. The duration of treatment may vary based on individual risk factors.
  • Ductal Carcinoma In Situ (DCIS): The recommended dosage for the treatment of DCIS is typically 20 mg once daily for 5 years.

Taking Nolvadex as directed is important, and consulting a healthcare professional before changing the dosage is important. If there are any concerns about the medication or its side effects, discussing them with the prescribing doctor is crucial. Additionally, regular follow-up appointments are often scheduled to monitor the effectiveness of the treatment and address any potential issues.

Important Safety Information

Tamoxifen may increase the risk of blood clots, which can be severe. Inform your healthcare provider if you have a history of blood clots or conditions that may predispose you to clotting.

Tamoxifen has been associated with an increased risk of uterine cancer. Report any unusual vaginal bleeding or symptoms to your healthcare provider promptly.

Rarely, Tamoxifen may cause vision problems. If you experience vision changes, notify your doctor.

Tamoxifen should not be used during pregnancy, as it may harm the unborn baby. Discuss the risks and benefits with your breastfeeding provider if you are breastfeeding.

Inform your doctor about all medications, including over-the-counter and herbal supplements, that you are taking. Some drugs may interact with tamoxifen.

Regular monitoring of liver function may be recommended during tamoxifen treatment.

Tamoxifen may cause hot flashes and changes in menstrual periods. Discuss any bothersome symptoms with your healthcare provider.

There is evidence that tamoxifen may have a protective effect on bone density. Still, discussing bone health with your doctor is essential, especially if you have other risk factors for osteoporosis.

Always take Nolvadex precisely as your healthcare provider prescribes, and consult them before stopping or changing the dosage. If you experience any unusual or severe side effects, seek medical attention promptly. Regular follow-up appointments are typically scheduled to monitor your response to treatment and address any concerns.


Certain conditions may contraindicate the use of Nolvadex (tamoxifen), meaning that the medication should not be used in individuals with these conditions due to the potential for serious adverse effects. Contraindications may include:

  • Pregnancy: Tamoxifen should not be used during pregnancy, as it may harm the unborn baby. It is important for women of childbearing age to use effective contraception during tamoxifen treatment.
  • History of Blood Clots: Individuals with a history of blood clots, deep vein thrombosis (DVT), or pulmonary embolism may be at an increased risk of further clotting, and tamoxifen could exacerbate this risk.
  • History of Stroke or Transient Ischemic Attack (TIA): Tamoxifen may increase the risk of stroke or TIA in some individuals.
  • Allergy or Hypersensitivity: Individuals who are allergic to tamoxifen or any of its components should not use the medication.
  • Severe Liver Disease: Tamoxifen is metabolized in the liver, and individuals with severe liver impairment may have difficulty processing the drug.
  • Concurrent Use with Certain Medications: Tamoxifen may interact with other medications. Inform your healthcare provider about all medications, including over-the-counter drugs and herbal supplements, that you are taking.

It’s crucial to discuss your medical history, current health status, and any medications you are taking with your healthcare provider before starting tamoxifen treatment. They will evaluate whether tamoxifen is appropriate for your situation and consider alternative treatment options. 

Side Effects

Like any medication, Nolvadex (tamoxifen) may cause side effects. It’s important to note that not everyone will experience these side effects, and some people may experience only mild symptoms. Common side effects of tamoxifen include:

  1. Hot Flashes: Tamoxifen may cause hot flashes similar to those experienced during menopause.
  2. Menstrual Changes: Women may experience changes in their menstrual periods, including irregularity.
  3. Vaginal Discharge or Dryness: Some women may notice changes in vaginal discharge or dryness.
  4. Mood Swings: Mood changes, including mood swings and feelings of depression, have been reported.
  5. Nausea and Vomiting: Some individuals may experience nausea and vomiting.
  6. Fatigue: Tamoxifen can cause fatigue or tiredness.
  7. Headache: Headaches are a possible side effect of tamoxifen.
  8. Bone Pain: Some people may experience bone or joint pain.
  9. Risk of Blood Clots: Tamoxifen may increase the risk of blood clots, which can be severe.
  10. Increased Risk of Uterine Cancer: There is a slightly increased risk of uterine cancer associated with tamoxifen use.

It’s essential to report any side effects to your healthcare provider, especially if they are severe or persistent. Additionally, there are more serious but less common side effects, so it’s crucial to be aware of any unusual symptoms and seek medical attention. Regular check-ups and monitoring during tamoxifen treatment are typically part of the healthcare plan to address any potential issues.


In case of an overdose of Nolvadex (tamoxifen), it’s important to seek immediate medical attention. While accidental overdose is relatively uncommon, it’s crucial to be aware of the symptoms of a potential overdose and take prompt action. Symptoms of an overdose may include:

  • unusual fatigue or weakness;
  • unexplained bruising or bleeding;
  • persistent nausea or vomiting;
  • abdominal pain;
  • confusion or changes in mental status;
  • seizures.

If you suspect an overdose or experience any of these symptoms, contact your local emergency services or go to the nearest emergency room. It’s essential to inform healthcare professionals about the overdose and provide details about the amount of tamoxifen ingested.

There is no specific antidote for tamoxifen overdose, and treatment is generally supportive. This may include measures to manage symptoms and provide appropriate medical care based on the individual’s condition.

As with any medication, it’s crucial to take tamoxifen precisely as prescribed by your healthcare provider and to store it in a safe place, away from the reach of children or others who may inadvertently take it. If you have any concerns or questions about your medication, don’t hesitate to contact your healthcare professional for guidance.

How to Store

Store Tamoxifen at room temperature, typically between 68°F to 77°F (20°C to 25°C). Avoid extreme temperatures.

Keep the medication in a dry place. Moisture can affect the stability of the drug.

Some medications can be sensitive to light. Store tamoxifen in its original packaging or in a light-resistant container to protect it from exposure to light.

Store tamoxifen in a location that is not easily accessible to children and pets. Consider using child-resistant packaging.

Always follow any specific pharmacy storage instructions or on the medication packaging.

While it might be a common practice, storing medications in the bathroom exposes them to humidity and changes in temperature, which may reduce their effectiveness.

Ensure that you check the expiration date on the medication. Do not use tamoxifen if it has passed its expiration date.

If you have any specific concerns about the storage of your medication or if you’re unsure about any aspect of its use, it’s advisable to consult your pharmacist or healthcare provider for guidance.

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