Paxil (Paroxetine)

Last updated on February 15, 2024

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Alternate names of Paxil

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Paroxetine (Paxil) lifts depression without affecting heart.

SSRIs Safe for Cardiac Patients

Selective Serotonin Reuptake Inhibitors (SSRIs) play a crucial role, and Paxil, or Paroxetine, stands as a prominent member of this class of medications. Let’s explore the safety of SSRIs, particularly Paxil, for individuals with cardiac concerns.

What Is Paxil (Paroxetine)?

Paxil is a widely prescribed antidepressant belonging to the class of SSRIs. It works by increasing serotonin levels, a neurotransmitter associated with mood regulation, in the brain. Paxil is often prescribed to treat various mental health conditions, including depression, anxiety disorders, panic attacks, and obsessive-compulsive disorder.


A study has found that paroxetine (Paxil/ SmithKline Beecham) effectively reduced depression in patients without affecting cardiac function. The study’s patients were administered paroxetine, an SSRI, nortriptyline, or a placebo. Of the 41 patients taking nortriptyline, heart rates increased by 11%, and 7 of the patients dropped out of the study because of potentially severe cardiovascular side effects, such as angina and sinus tachycardia. There is evidence that because depression can increase the risk of myocardial infarction and death, effective relief of depression may improve outcomes in cardiac patients.

Dosage Recommendations

When taking Paxil, following your healthcare provider’s instructions is essential. The general recommendations include taking Paxil once daily, with or without food. Missing a dose should be addressed promptly, but if it’s almost time for the next dose, it’s advisable to skip the missed one. Overdosing on Paxil can lead to severe complications, so adhering to the prescribed dosage is crucial.

Side Effects

While Paxil can be beneficial for many, it’s essential to be aware of potential side effects. Common side effects may include nausea, drowsiness, dry mouth, and insomnia. If these persist or worsen, you must notify your healthcare provider. Additionally, some individuals may experience more severe side effects, such as suicidal thoughts, serotonin syndrome, or allergic reactions. Seeking immediate medical attention for these symptoms is imperative.


Understanding potential drug interactions is crucial when taking Paxil. Inform your healthcare provider about all medications, including over-the-counter drugs, herbal supplements, and vitamins. Paxil may interact with certain medications, such as blood thinners, antiplatelet drugs, and other antidepressants. Combining Paxil with these substances can lead to adverse effects, emphasizing the importance of open communication with your healthcare team.

How to Store

Proper medication storage is vital to maintain its efficacy and safety. Store Paxil at room temperature, away from moisture and heat. Keep it out of reach of children and pets. Avoid storing Paxil in the bathroom, as humidity can affect its stability. If you have any questions about storage, consult your healthcare provider or pharmacist.

Paxil, a widely prescribed SSRI, can be a valuable tool in managing various mental health conditions. For cardiac patients, it’s crucial to communicate openly with healthcare providers, ensuring a comprehensive understanding of potential risks and benefits. With proper adherence to dosage recommendations, awareness of side effects, consideration of potential interactions, and appropriate storage, Paxil can be safely integrated into a cardiac patient’s treatment plan. Always consult your healthcare provider for personalized advice based on your unique health profile.

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