Tofranil (Imipramine) overnight shipping

Last updated on February 15, 2024

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What is the other name for Tofranil?

Tofranil may be marketed under different names in various countries. Some of them are the following: Antidep, Antideprin, Depramina, Depramine, Depranil, Deprinol, Depsonil, Elepsin, Ethipramine, Fixon, Imavate, Imidol, Imipra, Imipramin, Imipramina, Imipramini, Imipraminum, Imiprex, Imiprin, Imp-Tab, Impril, Janimine, Melipramin, Melipramine, Mepramin, Norfranil, Novo-Pramine, Novopramine, Pinor, Praminan, Primonil, Pryleugan, Surplix, Talpramin, Tipramine, Tofranil mite, Tolerade, Uni Imiprax, Venefon.

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tofranilWhat Is Imipramine (Tofranil)?

Imipramine, sold under the brand name Tofranil, is a tricyclic antidepressant (TCA) medication. It’s used to treat symptoms of depression, such as feelings of sadness, worthlessness, and loss of interest in daily activities. Additionally, it can be prescribed for enuresis (bed-wetting) in children.

Imipramine increases certain neurotransmitters, such as serotonin and norepinephrine, in the brain. These chemicals play a role in regulating mood and emotions.

As with any medication, it’s essential to take Imipramine under the guidance of a healthcare professional, as it can have potential side effects and interactions with other drugs. If you or someone you know is prescribed Imipramine, it’s crucial to follow the prescribed dosage and communicate any concerns or side effects with your healthcare provider.


The active ingredient in Tofranil is imipramine hydrochloride. As for the inactive ingredients, they can vary among different formulations and brands, such as generic versions. In addition to imipramine, typical formulations may include fillers, binders, and other substances to create the final medication. If you have specific concerns about allergies or reactions to certain ingredients, consulting with your healthcare provider or pharmacist is always a good idea.


It helps alleviate symptoms of depression, including low mood, lack of interest in activities, changes in sleep and appetite, and feelings of worthlessness.

In children, Imipramine is sometimes prescribed to address bed-wetting issues.

In some cases, it may be used to manage panic attacks and symptoms associated with panic disorder.

It’s important to note that a healthcare professional should direct the use of Imipramine, and the decision to prescribe it is based on a careful assessment of the individual’s condition. The medication may take some time to show its full effects, and it’s crucial to follow the prescribed dosage and not discontinue it abruptly without consulting a healthcare provider.

Dosage Sizes

The dosage of Imipramine (Tofranil) can vary based on the individual’s condition, age, and other factors. It’s essential to follow the specific dosage instructions the prescribing healthcare professional provides. Typically, Imipramine is taken orally in the form of tablets or capsules.

For depression, the usual starting dose for adults is around 75 mg per day, divided into multiple doses. The dosage may be increased gradually based on the individual’s response to the medication.

For enuresis (bed-wetting) in children, the dosage is often lower and is determined based on the child’s weight. It’s essential to follow the pediatrician’s guidance in this case.

As with any medication, it’s crucial to consult a healthcare provider before self-adjusting the dosage. If there are concerns about the dosage or potential side effects, it’s best to discuss them with the prescribing doctor, who can make appropriate adjustments if needed.

Important Safety Information

Take the medication exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking it without consulting your doctor.

Your doctor may need to monitor your progress and adjust the dosage accordingly. Attend follow-up appointments as scheduled.

Inform your healthcare provider about any other medications, including over-the-counter drugs and herbal supplements, that you are taking. Imipramine can interact with certain medications.

Limit or avoid alcohol consumption while taking Imipramine, as it can enhance the sedative effects of the medication.

Imipramine may cause drowsiness or dizziness. Be cautious when driving or operating machinery until you know how the medication affects you.

Inform your doctor about any existing medical conditions, especially heart problems, bipolar disorder, glaucoma, or a history of seizures.

Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The risks and benefits of using Imipramine during pregnancy or breastfeeding should be discussed with your healthcare provider.

Antidepressants, including Imipramine, may increase the risk of suicidal thoughts, especially in young adults. If you or someone you know experiences worsening depression, thoughts of self-harm, or suicidal thoughts, seek immediate medical attention.

Always consult your healthcare provider for personalized advice and address any specific concerns about Imipramine.


Imipramine (Tofranil) may not be suitable for everyone. Here are some contraindications and situations where the use of Imipramine should be approached with caution or avoided:

  1. Hypersensitivity: Do not take Imipramine if you have a known hypersensitivity or allergy to Imipramine or any of its components.
  2. Recent Heart Attack: If you have had a recent heart attack, Imipramine should be used with caution, and the decision to prescribe it will depend on the individual case.
  3. Monoamine Oxidase Inhibitors (MAOIs): Do not use Imipramine if you have taken a monoamine oxidase inhibitor (MAOI) within 14 days. The combination of Imipramine and MAOIs can lead to severe and potentially life-threatening reactions.
  4. Glaucoma: Imipramine can worsen narrow-angle glaucoma, so it should be avoided in individuals with this condition.
  5. Urinary Retention: If you have a history of urinary retention, Imipramine should be used with caution, as it may exacerbate this condition.
  6. Seizure Disorders: Imipramine may lower the seizure threshold, so individuals with a history of seizures should use it cautiously.
  7. Pregnancy and Breastfeeding: The use of Imipramine during pregnancy and breastfeeding should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider.

It’s crucial to provide your healthcare provider with a comprehensive medical history and inform them of any medications or supplements you are currently taking to ensure the safe and effective use of Imipramine. Always follow your doctor’s recommendations and seek medical advice if you have concerns or experience side effects.

Side Effects

Like any medication, Imipramine (Tofranil) can cause side effects. It’s essential to be aware of these potential side effects and to promptly inform your healthcare provider if you experience any unusual or severe symptoms. Common side effects may include:

  • Dry Mouth: This is a common side effect of Imipramine. Staying hydrated and chewing sugar-free gum or sucking on sugar-free candy may help alleviate dry mouth.
  • Constipation: Increase your fiber intake and stay hydrated to manage constipation. If it persists, consult your healthcare provider.
  • Blurred Vision: Imipramine can cause blurred vision. If you experience vision changes, inform your doctor.
  • Drowsiness: Imipramine may cause drowsiness, so avoid activities that require alertness until you know how the medication affects you.
  • Weight Gain: Some individuals may experience weight gain while taking Imipramine. Maintaining a healthy diet and exercise routine can help manage this.
  • Dizziness: Changes in position, such as standing up quickly, may cause dizziness. Take your time when moving from a sitting or lying position.
  • Increased Heart Rate: Imipramine can affect heart rate. Inform your doctor if you experience rapid or irregular heartbeat.
  • Difficulty Urinating: Some individuals may experience difficulty urinating. If you have a history of urinary problems, inform your healthcare provider.
  • Sexual Dysfunction: Imipramine may cause sexual side effects. Discuss any concerns with your doctor.
  • Sweating: Increased sweating is a possible side effect. Stay hydrated, and consider wearing lightweight clothing.

It’s important to note that not everyone will experience these side effects, and some may subside over time. If you have concerns about side effects or if they persist or worsen, consult your healthcare provider for guidance. Additionally, seek immediate medical attention if you experience severe side effects, such as chest pain, difficulty breathing, or signs of an allergic reaction.


An overdose of Imipramine (Tofranil) can be severe and requires immediate medical attention. If you suspect an overdose or if someone is showing signs of overdose, such as severe drowsiness, confusion, hallucinations, rapid heartbeat, or fainting, seek emergency medical help or contact your local poison control center.

Overdose symptoms can vary and may include:

  • confusion;
  • seizures;
  • hallucinations;
  • severe drowsiness;
  • fast or irregular heartbeat;
  • uncontrolled movements or shaking;
  • difficulty breathing;
  • loss of consciousness.

It’s important not to ignore the signs of a potential overdose, as prompt medical attention is crucial for a positive outcome. If possible, provide information about the amount of medication taken and any other substances that might have been ingested.

To prevent overdose, always take Imipramine precisely as prescribed by your healthcare provider. Do not adjust the dosage without consulting your doctor, and inform them of any other medications or substances you are taking to avoid potential interactions. Contact your healthcare provider for guidance if you have concerns about your medication or experience any unusual symptoms.

How to Store

Store Imipramine in a cool, dry place away from direct sunlight, heat, and moisture. Avoid storing it in the bathroom, as the humidity can affect the medication.

Keep it out of the reach of children and pets. Consider using a high, locked cabinet or a medication storage box.

Keep Imipramine in its original container with the label intact. This helps ensure you have the correct medication and dosage information.

Check the specific storage instructions on the medication packaging or consult your pharmacist. Some medications may have temperature requirements, and it’s important to follow them.

Do not expose Imipramine to extreme temperatures. Avoid freezing or overheating the medication.

Moisture can affect the stability of medications. Keep Imipramine in a dry environment and avoid storing it in places prone to moisture, such as the bathroom.

If you have unused or expired Imipramine, follow proper disposal guidelines. Many pharmacies and local authorities provide methods for safe medication disposal.

Always follow any specific storage instructions provided by your pharmacist or healthcare provider. If you have questions about the storage of Imipramine or any other medication, don’t hesitate to ask your healthcare professional or pharmacist for guidance.

Drugs Similar to Imipramine (Tofranil) or Generic

Imipramine (Tofranil) belongs to the class of tricyclic antidepressants (TCAs). Several other TCAs are similar to Imipramine, and they may be prescribed for similar indications. Some examples of TCAs include:

  1. Amitriptyline (Elavil): Like Imipramine, amitriptyline is used to treat depression. It may also be prescribed for other conditions, such as neuropathic pain and migraines.
  2. Nortriptyline (Pamelor): Nortriptyline is another TCA used for the treatment of depression. It is considered a metabolite of amitriptyline.
  3. Desipramine (Norpramin): Desipramine is used for the treatment of depression. It is a metabolite of Imipramine.
  4. Doxepin (Sinequan): Doxepin is used to treat depression and anxiety. It may also be prescribed for sleep disorders due to its sedative effects.
  5. Clomipramine (Anafranil): Clomipramine is a TCA used to treat obsessive-compulsive disorder (OCD) and may also be used for depression.

It’s important to note that while these medications share a typical class, they can have different side effect profiles and may affect individuals differently. The choice of antidepressants depends on various factors, including the individual’s medical history, the specific symptoms being addressed, and potential side effects.

Additionally, generic versions of Imipramine are available. Generic drugs contain the same active ingredient as the brand-name drug and are generally considered equivalent in terms of safety and effectiveness. If a generic version is available, it may be a more cost-effective option for some individuals.

Summarizing Table

Here is the table that summarizes the information above.

Prescribing Information for Imipramine (Tofranil ®)
Optimum Dosage Usual maximum 5 mg/kg/dayEnuresis: 0-6 yr — not indicated

6-12 yr — up to 50 mg/day

12+ — up to 75 mg/day

ADD with anxiety or depression:

note maximum dose

Depression: some improve at serum levels of 150-200 ng/L

Some adolescent anorexics and bulimics respond to 150-200 mg/day

Major Side-Effectsa Cardiovascular effects: ECG changes (T-wave and P-R intervals affected at doses approaching 5 mg/kg/day) without cardiac injury (10%-30%)

Epileptic seizures (<2%)

Drug Interactions Sedatives, Anticholinergics


Monoamine oxidase inhibitors

Minor Short-Term Transienta Side-Effects Anticholinergic effects: Dry mouth (>30%)

Blurred vision (10%-30%)

Constipation (10%-30%)

Sweating (10%-30%)

Delayed micturition (10%-30%); primarily in elderly

CNS effects:

Drowsiness (10%-30%)

Insomnia (10%-30%)

Excitement (10%-30%) (particularly in bi-polar patients) Headache (10%-30%)

Extrapyramidal effects:

Fine tremor (10%-30%)

Gastrointestinal distress (10%-30%)

Weight gain (>6 kg) (>30%)

Rash (<2%)

Cardiovascular effects:

Postural hypotension or dizziness (>30%)

Tachycardia (10%-30%)

Increase in blood pressure (at 3 mg/kg/day)b

Contra-indications Not to be used in conjunction with or within 14 days of using monoamine oxidase inhibitorsNot to be used in out-patient treatment of suicidal patients

Not to be used in presence of glaucoma

Caution with epilepsy

Drug Withdrawal Effects:

  • Abdominal pain, nausea, vomiting
  • Drowsiness
  • Decreased appetite
  • Tearfulness
  • Agitation
  • Malaise
  • Headache

Concurrent Treatment and Alternatives

Alarm blanket (enuresis)Psychotherapy

Family therapy

Behavior therapy

Hospitalization or residential treatment

a. Frequencies from Bezchilibnyk-Butler and Jeffries.

b. Reversible if medication is discontinued.

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