Fosamax (Alendronate)

Last updated on February 15, 2024

Alendronate 35mg, 70mg

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Alternate names of Fosamax

Acide alendronique, Acido alendronico, Acidum alendronicum, Actimax, Adronat, Adrovance, Aldromax, Aldron, Aldronac, Aldrox, Aledox, Aledrolet, Aledronato mk, Alefos, Alehelm, Alen-far, Alenat, Alenato, Alenax, Alendil, Alendo, Alendon, Alendor, Alendra, Alendral, Alendran, Alendratol, Alendris, Alendro, Alendro-Q, Alendro-q, AlendroLEK, Alendrobell, Alendrocare, Alendrogen, Alendrohexal, Alendrolek, Alendromax, Alendromet, Alendron, Alendron-hexal, Alendronat, Alendronato, Alendronatum, Alendronax, Alendroninezuur, Alendronstad, Alendros, Alenic, Alenotop, Alenwin, Aleostito, Aliot, Alovell, Aloxin, Alxis, Ampine, Andante, Apodrolen, Arendal, Armol, Arthroplus, Aurodren, Beenos, Berlex, Bestalen, Bifemelan, Bifoal Semanal, Bifoal semanal, Bifosa, Bifosal, Blindafe, Blocan, Bonacton, Bonalen, Bonalon, Bonedron, Bonemax, Brek, Caldronate, Caltera, Carmotin, Cetrix, Cleveron, Dargol, Debenal, Defixal, Delfoza, Denfos, Deparex, Difonate, Discozal, Doryx, Drofaz, Dronadil, Dronak, Dronal, Dronalent, Dronat, Dronatex, Dronatifer, Dronet, Drovitan, Durost, Elandur, Eldinir, En-Por, En-por, Endronal, Endronax, Enimon, Epolar, Eucalen, Farmemax, Femide, Filxine, Findeclin, Findeclin Combi, Fixopan, Flamisul, Forosa, Fortimax, Fosagen, Fosalan, Fosalen, Fosamac, Fosandron, Fosaplus, Fosavance, Fosazom, Fosfacid, Fosmin, Fosteofos, Fostepor, Fostolin, Fosval, Genalen, Gendron, Holadren, Huesobone, Jamax-S, Lafedam, Landrolen, Ledronin, Lendral, Lendronal, Leodrin, Lindron, Lokar, Lozostun, Marvil, Massidron, Maxibone, Maxtral, Minusorb, Moralen, Mosmass, Nafadren, Neobon, Nichospor, Norvic, Nozat, Onclast, Osalen, Osaston, Osdren, Osdron, Oseolen, Oseomax, Oseotal, Oseotenk, Osficar, Ossmax, Osso, Ossomax, Ostadil, Ostaham, Ostalert, Ostat, Ostaven, Ostel, Ostemax, Ostenan, Ostenil, Osteobon, Osteodur, Osteofar, Osteofel, Osteofene, Osteoform, Osteofos, Osteomax, Osteomel, Osteomix, Osteonat, Osteonate, Osteonorm, Osteoral, Osteosan, Osteotrat, Ostex, Ostolek, Ostomax, Pamoseo, Pasodron, Phostarac, Poris, Porocalm, Porodron, Porolen, Porosal, Porosimax, Porosin, Promax, Ralenost, Randronate, Recalfe, Regenesis, Rekostin, Reyoin, Ridon, Riledron, Romax, Sedron, Silidral, Sinfract, Siranin, Stada, Sumax, Synostep, Teiroc, Terost, Teva nate, Tevabone, Tevalen, Tevanate, Tilios, Tivarun, Tonadron, Trabecan, Tratos, Valora, Vegabon, Voroste, Zondra, Zophost

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Alendronate (a LEN droe nate)

ALENDRONATEWhat Is Alendronate?

Alendronate is a medication that belongs to a class of drugs called bisphosphonates. It is commonly used to treat osteoporosis and other bone conditions. Osteoporosis is a condition characterized by the weakening of the bones, making them more prone to fractures.

Alendronate works by inhibiting the activity of cells called osteoclasts, which are responsible for breaking down bone tissue. By slowing down bone resorption, Alendronate helps to maintain or increase bone density, reducing the risk of fractures.

It’s typically taken orally, and following the prescribed dosage and any instructions provided by your healthcare provider is essential. As with any medication, there can be potential side effects, so discussing any concerns or questions with your doctor is crucial.

Ingredients of Alendronate

The main ingredient is alendronate sodium. It is a bisphosphonate drug used to treat various bone conditions, most commonly osteoporosis. Alendronate works by inhibiting osteoclast activity, the cells responsible for breaking down bone tissue. By slowing down bone resorption, alendronate helps to increase bone density and reduce the risk of fractures in individuals with conditions characterized by bone loss.

When alendronate is prescribed, it is typically in the form of alendronate sodium. The sodium salt form is used for oral administration.


Oral Tablets

White round uncoated (5mg), White oval wax polished (10mg), White oval uncoated (35mg), White triangular uncoated (40mg), White oval uncoated (70mg) tablets (Merck Frosst Brand). Other brands may have different appearances.

Oral Solution

Clear, colorless oral solution with a raspberry flavor (70mg/bottle).


Alendronate is used to prevent osteoporosis in women who have undergone menopause. Alendronate is also used to treat osteoporosis in men and women who have developed the disease due to natural causes or drugs. Alendronate is also used to treat Paget’s disease of the bone. Alendronate is in a class of medications called bisphosphonates. It prevents bone breakdown and increases bone density (thickness) to make bones stronger and less likely to break.

How to Take

Oral Tablets or Solution: Tablets may be taken once a day or once a week, depending on the dose ordered, with a full glass of water (6-8oz) first thing in the morning. After taking Alendronate, wait at least 30 minutes before taking any food, beverage, or other medication, including antacids, calcium supplements, and vitamins. Alendronate is most effective only if taken when your stomach is empty. You should not chew or suck on the tablets; swallow them whole. Do not lie down for at least 30 minutes after taking this medication. Drink at least a quarter of a cup (2 oz or 60ml) of water after taking the oral solution.


If you are pregnant or breastfeeding, you should not be taking Alendronate. You should not take Alendronate if you have stomach or intestine problems or kidney disease. Tell your doctor if you have had trouble with any of these problems and if you have trouble standing or sitting upright for at least 30 minutes.

Alendronate should not be taken at the same time as any other medication. Do not take antacids or any other prescription (or over-the-counter) medications containing calcium, iron, magnesium, or aluminum at the same time as you take Alendronate tablets. If you must take other medications, they should be taken at least 1 to 2 hours after taking Alendronate. Check with your doctor or pharmacist if unsure how and when to take your medications.

Your Doctor may ask you to take a calcium and vitamin D supplement in addition to Alendronate. If you do, remember to take these vitamins at a different time of day than the Risedronate. Do not take calcium and vitamin D if your blood has high calcium levels.

Store at room temperature in a well-closed container. Keep out of the reach of children.

Please call your doctor, pharmacist, or nurse for more information on this medication.

Side Effects

  • Nausea, vomiting, diarrhea
  • Stomach pain
  • Chest pain, heartburn
  • Esophageal irritation (difficulty or pain upon swallowing)
  • Take tablet with a full glass of water
  • Do not lie down for 30 minutes after taking the tablet
  • Tell your doctor or nurse if these symptoms bother you
  • Tell your doctor or nurse if these become a problem
  • Mouth irritation
  • Muscle pain, Joint pain
  • Rash, itching or eye pain
  • Swallow tablet whole. Do not chew or split the tablet.
  • Tell your doctor or nurse if this bothers you.
  • One or two regular strength acetaminophen tablets (Tylenol®) may help.
  • Tell your doctor or nurse as soon as possible


Alendronate may not be suitable for everyone, and there are specific contraindications or situations where its use may be discouraged. Some contraindications and precautions include:

  1. Hypersensitivity: Individuals with a known hypersensitivity or allergy to Alendronate or its components should avoid using it.
  2. Esophageal Abnormalities: Alendronate can potentially irritate the esophagus. Therefore, individuals with conditions that may delay esophageal emptying, such as strictures or achalasia, should use Alendronate cautiously.
  3. Inability to Stand or Sit Upright: Patients who cannot stand or sit upright for at least 30 minutes should not take Alendronate, as it’s important to remain upright during and after taking the medication to reduce the risk of esophageal irritation.
  4. Impaired Renal Function: Alendronate is excreted by the kidneys, so individuals with severe renal impairment may need dose adjustments or should avoid the medication.
  5. Calcium and Vitamin D Deficiency: Adequate intake of calcium and vitamin D is essential for the effectiveness of Alendronate. Individuals with deficiencies may need supplementation.

Always inform your healthcare provider about your complete medical history, including any existing conditions or medications you are taking, before starting Alendronate or any new medication. This helps ensure that the treatment is safe and appropriate for you.


If you suspect an overdose of alendronate or experience symptoms such as difficulty swallowing, chest pain, heartburn, stomach pain, or nausea, it’s crucial to seek emergency medical attention immediately. Overdosing on Alendronate can lead to severe complications, including esophageal irritation and ulceration.

In case of overdose, the individual should not induce vomiting unless instructed by a healthcare professional. Instead, supportive care will be provided, including measures to protect the esophagus and gastrointestinal tract.

Staying within the prescribed Alendronate dosage and following the recommended administration instructions is essential. If you have concerns about your medication or if you accidentally take more than the prescribed dose, contact your healthcare provider or seek emergency medical attention promptly.

How to Store

Store Alendronate at room temperature, away from extreme heat and cold. Avoid exposing it to temperatures above 25°C (77°F).

Keep the medication in its original packaging and protect it from moisture. Avoid storing it in the bathroom or other humid environments.

Store it in a container that protects it from light. Please keep it in a dark, cool place.

Keep Alendronate and other medications out of the reach of children and pets. Consider using childproof containers to prevent accidental ingestion.

Check the expiration date on the medication packaging. Do not use Alendronate after the expiration date has passed.

Always follow any specific storage instructions provided by your pharmacist or healthcare provider. If you have any doubts about the storage of your medication or if it has been exposed to unfavorable conditions, consult with your healthcare professional or pharmacist. Never use medications that appear damaged, discolored, or have an unusual odor.

Other Names for This Medication (Brand Names)

Adronat, Alendros, Arendal, Apo-Alendronate, Fosamax, Novo-Alendronate, Onclast

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