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Augmentin (Amoxicillin And Clavulanate)

Last updated on October 26, 2021

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Augmentin 125/31 SF Suspension

Co-amoxiclav (Amoxicillin and Clavulanic Acid)

Augmentin is an antibiotic and works by killing bacteria that cause infections. It contains two different medicines called amoxicillin and clavulanic acid. Amoxicillin belongs to a group of medicines called “penicillins” that can sometimes be stopped from working (made inactive). The other active component (clavulanic acid) stops this from happening.

Augmentin is used in babies and children tAmoxicillino treat the following infections:

  • middle ear and sinus infections
  • respiratory tract infections
  • urinary tract infections
  • skin and soft tissue infections including dental infections
  • bone and joint infections.

Do not give your child Augmentin:

  • if they are allergic (hypersensitive) to amoxicillin, clavulanic acid or any of the other ingredients of Augmentin (listed in section 6)
  • if they have ever had a severe allergic (hypersensitive) reaction to any other antibiotic. This can include a skin rash or swelling of the face or neck
  • if they have ever had liver problems or jaundice (yellowing of the skin) when taking an antibiotic.

Do not give Augmentin to your child if any of the above apply to your child.

If you are not sure, talk to their doctor or pharmacist before giving  Augmentin.

Take special care with Augmentin

Check with their doctor or pharmacist before giving your child this medicine if they:

  • have glandular fever
  • are being treated for liver or kidney problems
  • are not passing water regularly.

If you are not sure if any of the above apply to your child, talk to their doctor or pharmacist before giving Augmentin.

In some cases, your doctor may investigate the type of bacteria that is causing your child’s infection. Depending on the results, your child may be given a different strength of Augmentin or a different medicine.

Conditions you need to look out for

Augmentin can make some existing conditions worse, or cause serious side effects. These include allergic reactions, convulsions (fits) and inflammation of the large intestine. You must look out for certain symptoms while your child is taking Augmentin, to reduce the risk of any problems.

Blood or urine tests

If your child is having blood tests (such as red blood cell status tests or liver function tests) or urine tests, let the doctor or nurse know that they are taking Augmentin. This is because Augmentin can affect the results of these types of tests.

AmoxicillinUsing other medicines

Please tell your doctor or pharmacist if your child is taking or has recently taken any other medicines. This includes medicines that can be bought without a prescription and herbal medicines.

If your child is taking allopurinol (used for gout) with Augmentin, it may be more likely that they will have an allergic skin reaction.

If your child is taking probenecid (used for gout), your doctor may decide to adjust the dose of Augmentin.

If medicines to help stop blood clots (such as warfarin) are taken with Augmentin then extra blood tests may be needed.

Augmentin can affect how methotrexate (a medicine used to treat cancer or rheumatic diseases) works.

Pregnancy and breast-feeding

If your child who is about to take this medicine is pregnant or breast-feeding, please tell your doctor or pharmacist.

Ask your doctor or pharmacist for advice before taking any medicine.

Important information about some of the ingredients of Augmentin

Augmentin contains aspartame (E951) which is a source of phenylalanine. This may be harmful for children born with a condition called ‘phenylketonuria’.

Augmentin contains maltodextrin (glucose). If you have been told by your doctor that your child has an intolerance to some sugars, contact your doctor before taking this medicinal product.

Always give Augmentin exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

Adults and children weighing 40 kg or over

This suspension is not usually recommended for adults and children weighing 40 kg and over. Ask your doctor or pharmacist for advice.

Children weighing less than 40 kg

All doses are worked out depending on the child’s bodyweight in kilograms.

Your doctor will advise you how much Augmentin you should give to your baby or child.

You may be provided with a plastic measuring spoon or measuring cup. You should use this to give the correct dose to your baby or child.

Usual dose – 20 mg/5 mg to 60 mg/15 mg for each kilogram of bodyweight a day, given in three divided doses.

Patients with kidney and liver problems

  • If your child has kidney problems the dose might be lowered. A different strength or a different medicine may be chosen by your doctor.
  • If your child has liver problems they may have more frequent blood tests to see how their liver is working.

How to give Augmentin

Always shake the bottle well before each dose

Give at the start of a meal or slightly before

Space the doses evenly during the day, at least 4 hours apart. Do not take 2 doses in 1 hour.

Do not give your child Augmentin for more than 2 weeks. If your child still feels unwell they should go back to see the doctor.

If you give more Augmentin than you should

If you give your child too much Augmentin, signs might include an upset stomach (feeling sick, being sick or diarrhoea) or convulsions. Talk to their doctor as soon as possible. Take the medicine bottle to show the doctor.

If you forget to give Augmentin

If you forget to give your child a dose, give it as soon as you remember. You should not give your child the next dose too soon, but wait about 4 hours before giving the next dose.

If your child stops taking Augmentin

Keep giving your child Augmentin until the treatment is finished, even if they feel better. Your child needs every dose to help fight the infection. If some bacteria survive they can cause the infection to come back.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Like all medicines, Augmentin can cause side effects, although not everybody gets them. The side effects below may happen with this medicine.

Conditions you need to look out for

Allergic reactions:
  • skin rash
  • inflammation of blood vessels (vasculitis) which may be visible as red or purple raised spots on the skin, but can affect other parts of the body
  • fever, joint pain, swollen glands in the neck, armpit or groin
  • swelling, sometimes of the face or mouth (angioedema), causing difficulty in breathing
  • collapse.

Contact a doctor immediately if your child gets any of these symptoms. Stop taking Augmentin.

Inflammation of large intestine

Inflammation of the large intestine, causing watery diarrhoea usually with blood and mucus, stomach pain and/or fever. Contact your doctor as soon as possible for advice if your child gets these symptoms.

Very common side effects

These may affect more than 1 in 10 people – diarrhoea (in adults).

Common side effects

  • These may affect up to 1 in 10 people
  • thrush (Candida – a yeast infection of the vagina, mouth or skin folds)
  • feeling sick (nausea), especially when taking high doses

–    if affected take Augmentin before food

  • vomiting
  • diarrhoea (in children).

Uncommon side effects

These may affect up to 1 in 100 people

  • skin rash, itching
  • raised itchy rash (hives)
  • indigestion
  • dizziness
  • headache.

Uncommon side effects that may show up in blood tests:

increase in some substances (enzymes) produced by the liver.

Rare side effects

These may affect up to 1 in 1000 people

  • skin rash, which may blister, and looks like small targets (central dark spots surrounded by a paler area, with a dark ring around the edge – erythema multiforme)

if you notice any of these symptoms contact a doctor urgently.

Rare side effects that may show up in blood tests:

  • low number of cells involved in blood clotting
  • low number of white blood cells.

Other side effects

Other side effects have occurred in a very small number of people but their exact frequency is unknown.

  • Allergic reactions (see above)
  • Inflammation of the large intestine (see above)
  • Serious skin reactions:

–    a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals {Stevens-Johnson syndrome), and a more severe form, causing  extensive peeling of the skin (more than 30% of the body surface – toxic epidermal necrolysis)

widespread red skin rash with small pus-containing blisters {bullous exfoliative dermatitis)

a red, scaly rash with bumps under the skin and blisters {exanthemouspustulosis).

Contact a doctor immediately if your child gets any of these symptoms.

  • inflammation of the liver (hepatitis)
  • jaundice, caused by increases in the blood of bilirubin (a substance produced in the liver) which may make your child’s skin and whites of the eyes appear yellow
  • inflammation of tubes in the kidney
  • blood takes longer to clot
  • hyperactivity
  • convulsions (in people taking high doses of Augmentin or who have kidney problems)
  • black tongue which looks hairy
  • stained teeth (in children), usually removed by brushing.

Side effects that may show up in blood or urine tests:

  • severe reduction in the number of white blood cells
  • low number of red blood cells {haemolytic anaemia)
  • crystals in urine.

If your child gets side effects

  • Tell your doctor or pharmacist if any of the side effects become severe or troublesome, or if you notice any side effects not listed in this post.
  • Keep out of the reach and sight of children.
  • Do not use Augmentin after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
  • The expiry date which is stated on the bottle label is for the pharmacist’s use. The pharmacist will have made up your medicine. It should be used within 7 days.
  • Store in the fridge, but do not freeze.
  • Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

What Augmentin contains

  • The active substances are 125 mg amoxicillin and 31.25 mg clavulanic acid (present as potassium clavulanate) in every 5 ml of suspension
  • The other ingredients are xanthan gum (E415), hydroxypropyl methylcellulose (E464), aspartame (see section 2), silicon dioxide, colloidal silica, succinic acid, raspberry, orange and golden syrup flavours and water.

What Augmentin looks like and contents of the pack

A clear glass bottle containing 100 ml of an off-white liquid mixture called a suspension. The bottle is supplied in a carton.

Advice/medical education

Antibiotics are used to treat infections caused by bacteria. They have no effect against infections caused by viruses.

Sometimes an infection caused by bacteria does not respond to a course of an antibiotic. One of the commonest reasons for this to occur is because the bacteria causing the infection are resistant to the antibiotic that is being taken. This means that they can survive and even multiply despite the antibiotic.

Bacteria can become resistant to antibiotics for many reasons. Using antibiotics carefully can heta to reduce the chance of bacteria becomina

When your doctor prescribes a course of an antibiotic it is intended to treat only your current illness. Paying attention to the following advice will help prevent the emergence of resistant bacteria that could stop the antibiotic working.

  1. It is very important that you take the antibiotic at the right dose, at the right times and for the right number of days. Read the instructions on the label and if you do not understand anything ask your doctor or pharmacist to explain.
  2. You should not take an antibiotic unless it has been prescribed specifically for you and you should use it only to treat the infection for which it was prescribed.
  3. You should not take antibiotics that have been prescribed for other people even if they had an infection that was similar to yours.
  4. You should not give antibiotics that were prescribed for you to other people.
  5. If you have any antibiotic left over when you have taken the course as directed by your doctor you should take the remainder to a pharmacy
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